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In vitro Dissolution, Cellular Membrane Permeability and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles

Overview of attention for article published in Molecular Pharmaceutics, November 2017
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (65th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

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5 tweeters
facebook
1 Facebook page

Citations

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13 Dimensions

Readers on

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19 Mendeley
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Title
In vitro Dissolution, Cellular Membrane Permeability and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles
Published in
Molecular Pharmaceutics, November 2017
DOI 10.1021/acs.molpharmaceut.7b00529
Pubmed ID
Authors

Estelle Juère, Justyna Florek, Meryem Bouchoucha, Siddharth Jambhrunkar, Kuan Yau Wong, Amirali Popat, Freddy Kleitz

Abstract

Sizing drugs down to the sub-micron and nanometer scale using nanoparticles has been extensively used in pharmaceutical industries to overcome the poor aqueous solubility of potential therapeutic agents. Here, we report the encapsulation and release of resveratrol, a promising anti-inflammatory and anticancer nutraceutical, from the mesopores of MCM-48-type silica nanospheres of various particle sizes, i.e., 90, 150, and 300 nm. Furthermore, the influence of the carrier pore size on drug solubility was also evaluated (3.5 vs. 7 nm). From our results, it is observed that the saturated solubility could depend not only on the pore size but also on the particle size of the nanocarriers. Moreover, with our resveratrol-mesoporous silica nanoparticles formulation, we have observed that the permeability of resveratrol encapsulated in MCM-48 nanoparticles (90 nm) can be enhanced compared to a resveratrol suspension when tested through the human colon carcinoma cell monolayer (Caco-2). Using an in vitro NF-κB assay, we showed that resveratrol encapsulation did not alter its bioactivity and, at lower concentration, i.e., 5 μg ml-1, resveratrol encapsulation provided higher anti-inflammatory activity compared to both resveratrol suspension and solution. All combined, the reported results clearly highlight the potential of small size mesoporous silica nanoparticles as next generation nanocarriers for hydrophobic drugs and nutraceuticals.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 5%
Unknown 18 95%

Demographic breakdown

Readers by professional status Count As %
Unspecified 4 21%
Student > Ph. D. Student 4 21%
Student > Bachelor 3 16%
Researcher 3 16%
Other 2 11%
Other 3 16%
Readers by discipline Count As %
Unspecified 8 42%
Chemistry 3 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Medicine and Dentistry 2 11%
Computer Science 1 5%
Other 3 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 December 2017.
All research outputs
#3,520,167
of 12,361,048 outputs
Outputs from Molecular Pharmaceutics
#491
of 2,248 outputs
Outputs of similar age
#99,806
of 292,359 outputs
Outputs of similar age from Molecular Pharmaceutics
#10
of 117 outputs
Altmetric has tracked 12,361,048 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 2,248 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.