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Hippocampal GABA enables inhibitory control over unwanted thoughts

Overview of attention for article published in Nature Communications, November 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
73 news outlets
blogs
13 blogs
twitter
213 tweeters
facebook
25 Facebook pages
wikipedia
1 Wikipedia page
googleplus
91 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
88 Dimensions

Readers on

mendeley
311 Mendeley
citeulike
1 CiteULike
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Title
Hippocampal GABA enables inhibitory control over unwanted thoughts
Published in
Nature Communications, November 2017
DOI 10.1038/s41467-017-00956-z
Pubmed ID
Authors

Taylor W. Schmitz, Marta M. Correia, Catarina S. Ferreira, Andrew P. Prescot, Michael C. Anderson

Abstract

Intrusive memories, images, and hallucinations are hallmark symptoms of psychiatric disorders. Although often attributed to deficient inhibitory control by the prefrontal cortex, difficulty in controlling intrusive thoughts is also associated with hippocampal hyperactivity, arising from dysfunctional GABAergic interneurons. How hippocampal GABA contributes to stopping unwanted thoughts is unknown. Here we show that GABAergic inhibition of hippocampal retrieval activity forms a key link in a fronto-hippocampal inhibitory control pathway underlying thought suppression. Subjects viewed reminders of unwanted thoughts and tried to suppress retrieval while being scanned with functional magnetic resonance imaging. Suppression reduced hippocampal activity and memory for suppressed content. (1)H magnetic resonance spectroscopy revealed that greater resting concentrations of hippocampal GABA predicted better mnemonic control. Higher hippocampal, but not prefrontal GABA, predicted stronger fronto-hippocampal coupling during suppression, suggesting that interneurons local to the hippocampus implement control over intrusive thoughts. Stopping actions did not engage this pathway. These findings specify a multi-level mechanistic model of how the content of awareness is voluntarily controlled.

Twitter Demographics

The data shown below were collected from the profiles of 213 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 311 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 311 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 59 19%
Student > Master 43 14%
Student > Bachelor 39 13%
Researcher 37 12%
Student > Postgraduate 16 5%
Other 56 18%
Unknown 61 20%
Readers by discipline Count As %
Psychology 80 26%
Neuroscience 63 20%
Medicine and Dentistry 17 5%
Agricultural and Biological Sciences 16 5%
Biochemistry, Genetics and Molecular Biology 11 4%
Other 42 14%
Unknown 82 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 887. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2022.
All research outputs
#15,566
of 22,562,129 outputs
Outputs from Nature Communications
#283
of 46,242 outputs
Outputs of similar age
#312
of 344,284 outputs
Outputs of similar age from Nature Communications
#14
of 2,300 outputs
Altmetric has tracked 22,562,129 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,242 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 2,300 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.