Title |
Analogues ofPseudomonas aeruginosasignalling molecules to tackle infections
|
---|---|
Published in |
Organic and Biomolecular Chemistry, January 2018
|
DOI | 10.1039/c7ob02395b |
Pubmed ID | |
Authors |
Eoin Ó Muimhneacháin, F. Jerry Reen, Fergal O'Gara, Gerard P. McGlacken |
Abstract |
The emergence of antibiotic resistance coupled with the lack of investment by pharmaceutical companies necessitates a new look at how we tackle bacterial infections. An intriguing tactic is the interruption of bacterial communication systems. This non-biocidal approach would circumvent the evolutionary pressure on bacteria to mutate and develop resistance. In many pathogenic microorganisms, communication systems, collectively termed quorum sensing (QS), have been observed to control a number of bacterial behaviours including expression of virulence factors and the development of biofilms. QS signalling molecules and their biomimetics, therefore, represent a rational target for the disruption of cooperative behaviour and thus the development of novel antimicrobial strategies. Herein we review recent developments towards the interference of Pseudomonas aeruginosa QS using signalling molecules and their mimetics. |
Twitter Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 42 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 19% |
Student > Ph. D. Student | 8 | 19% |
Student > Bachelor | 7 | 17% |
Student > Doctoral Student | 6 | 14% |
Student > Postgraduate | 3 | 7% |
Other | 5 | 12% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 9 | 21% |
Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Immunology and Microbiology | 6 | 14% |
Agricultural and Biological Sciences | 5 | 12% |
Engineering | 2 | 5% |
Other | 5 | 12% |
Unknown | 8 | 19% |