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Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium

Overview of attention for article published in International Journal of Retina and Vitreous , October 2017
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1 tweeter

Citations

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9 Dimensions

Readers on

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16 Mendeley
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Title
Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium
Published in
International Journal of Retina and Vitreous , October 2017
DOI 10.1186/s40942-017-0095-6
Pubmed ID
Authors

Rodrigo A. Brant Fernandes, Francisco R. Stefanini, Paulo Falabella, Michael J. Koss, Trent Wells, Bruno Diniz, Ramiro Ribeiro, Paulo Schor, Mauricio Maia, Fernando M. Penha, David R. Hinton, Yu-Chong Tai, Mark Humayun

Abstract

Subretinal cell transplantation is a challenging surgical maneuver. This paper describes the preliminary findings of a new tissue injector for subretinal implantation of an ultrathin non-absorbable substrate seeded with human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE). Ultrathin Parylene-C substrates measuring 3.5 mm × 6.0 mm seeded with hESC-RPE (implant referred to as CPCB-RPE1) were implanted into the subretinal space of 12 Yucatan minipigs. Animals were euthanized immediately after the procedure and underwent spectral domain optical coherence tomography (SD-OCT) and histological analysis to assess the subretinal placement of the implant. Evaluation of the hESC-RPE cells seeded on the substrate was carried out before and after implantation using standard cell counting techniques. The tissue injector delivered the CPCB-RPE1 implant through a 1.5 mm sclerotomy and a 1.0-1.5 mm retinectomy. SD-OCT scans and histological examination revealed that substrates were precisely placed in the subretinal space, and that the hESC-RPE cell monolayer continued to cover the surface of the substrate after the surgical procedure. This innovative tissue injector was able to efficiently deliver the implant in the subretinal space of Yucatan minipigs, preventing significant hESC-RPE cell loss, minimizing tissue trauma, surgical complications and postoperative inflammation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 25%
Student > Ph. D. Student 2 13%
Professor 2 13%
Professor > Associate Professor 2 13%
Other 2 13%
Other 3 19%
Unknown 1 6%
Readers by discipline Count As %
Engineering 3 19%
Medicine and Dentistry 3 19%
Agricultural and Biological Sciences 3 19%
Biochemistry, Genetics and Molecular Biology 2 13%
Chemistry 1 6%
Other 1 6%
Unknown 3 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2018.
All research outputs
#8,647,096
of 13,793,900 outputs
Outputs from International Journal of Retina and Vitreous
#18
of 77 outputs
Outputs of similar age
#183,810
of 316,221 outputs
Outputs of similar age from International Journal of Retina and Vitreous
#4
of 9 outputs
Altmetric has tracked 13,793,900 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 77 research outputs from this source. They receive a mean Attention Score of 1.9. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,221 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.