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KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL

Overview of attention for article published in Blood, October 2014
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Title
KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL
Published in
Blood, October 2014
DOI 10.1182/blood-2014-03-565069
Pubmed ID
Authors

Lena Oevermann, Sebastian U. Michaelis, Markus Mezger, Peter Lang, Jacek Toporski, Alice Bertaina, Marco Zecca, Lorenzo Moretta, Franco Locatelli, Rupert Handgretinger

Abstract

We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
France 1 2%
Italy 1 2%
Brazil 1 2%
United States 1 2%
Unknown 46 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 33%
Student > Ph. D. Student 9 18%
Unspecified 6 12%
Student > Doctoral Student 5 10%
Other 4 8%
Other 10 20%
Readers by discipline Count As %
Medicine and Dentistry 25 49%
Agricultural and Biological Sciences 10 20%
Unspecified 8 16%
Immunology and Microbiology 4 8%
Biochemistry, Genetics and Molecular Biology 4 8%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2014.
All research outputs
#9,905,254
of 12,371,951 outputs
Outputs from Blood
#14,579
of 16,574 outputs
Outputs of similar age
#153,639
of 228,569 outputs
Outputs of similar age from Blood
#234
of 318 outputs
Altmetric has tracked 12,371,951 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,574 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 318 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.