Title |
Effectiveness of option B highly active antiretroviral therapy (HAART) prevention of mother-to-child transmission (PMTCT) in pregnant HIV women
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Published in |
BMC Research Notes, January 2014
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DOI | 10.1186/1756-0500-7-52 |
Pubmed ID | |
Authors |
Erastus K Ngemu, Christopher Khayeka-Wandabwa, Eliningaya J Kweka, Joseph K Choge, Edward Anino, Elijah Oyoo-Okoth |
Abstract |
Ensuring that no baby is born with HIV is an essential step towards achieving an AIDS-free generation. To achieve this, strategies that decouple links between childbirth and HIV transmission are necessary. Traditional forms of prevention of mother-to-child transmission of HIV (PMTCT), has been recommended. Recognizing the importance and challenges of combination of methods to achieve rapid PMTCT, the World Health Organization (WHO) recommended option B Highly Active Antiretroviral Therapy (HAART) for all HIV-positive pregnant women. This study aimed to evaluate the effectiveness of the HAART in PMTCT. A cohort of HIV-infected pregnant women in Kenya were obtained from the DREAM Center, Nairobi. The study participants underwent adherence counselling and Option B of HAART [Nevirapine(NVP) + Lamivudine + Zidovudine] at the fourth week of gestation followed by an intravenous NVP administration intrapartum and postpartum NVP syrup to the respective infants for six weeks. Absolute pre-HAART and post-HAART CD4 counts and viral loads counts were determined. Comparison of the CD4 counts and viral loads before and after administration of HAART were done using Wilcoxon's Matched Pairs Signed-Ranks Test. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Switzerland | 1 | <1% |
Sudan | 1 | <1% |
Botswana | 1 | <1% |
Kenya | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Unknown | 203 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 62 | 30% |
Student > Postgraduate | 22 | 11% |
Student > Ph. D. Student | 20 | 10% |
Researcher | 18 | 9% |
Student > Bachelor | 17 | 8% |
Other | 32 | 15% |
Unknown | 38 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 77 | 37% |
Nursing and Health Professions | 26 | 12% |
Agricultural and Biological Sciences | 18 | 9% |
Social Sciences | 14 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 3% |
Other | 24 | 11% |
Unknown | 44 | 21% |