Title |
Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review
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Published in |
Clinical Infectious Diseases, October 2014
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DOI | 10.1093/cid/ciu785 |
Pubmed ID | |
Authors |
Benjamin Lazarus, David L Paterson, Joanne L Mollinger, Benjamin A Rogers |
Abstract |
To find out whether food-producing animals (FPA) are a source of extraintestinal expanded-spectrum-cephalosporin-resistant Escherichia coli (ESCR-EC) infections in humans, MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews were systematically reviewed. Thirty-four original, peer-reviewed publications were identified for inclusion. Six molecular epidemiology studies supported the transfer of resistance via whole bacterium transmission (WBT), which was best characterized amongst poultry in The Netherlands. Thirteen molecular epidemiology studies supported transmission of resistance via mobile genetic elements (MGE), which demonstrated greater diversity of geography and host FPA. Seventeen molecular epidemiology studies did not support WBT and two did not support MGE-mediated transmission. Four observational epidemiology studies were consistent with zoonotic transmission. Overall, there is evidence that a proportion of human extraintestinal ESCR-EC infections originate from FPA. Poultry in particular is probably a source, but the quantitative and geographical extent of the problem is unclear and requires further investigation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 4 | 22% |
Australia | 2 | 11% |
United Kingdom | 2 | 11% |
United States | 1 | 6% |
Unknown | 9 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 50% |
Scientists | 6 | 33% |
Practitioners (doctors, other healthcare professionals) | 3 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | <1% |
Brazil | 1 | <1% |
India | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
United States | 1 | <1% |
Unknown | 313 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 51 | 16% |
Student > Master | 48 | 15% |
Researcher | 43 | 13% |
Student > Bachelor | 28 | 9% |
Student > Doctoral Student | 26 | 8% |
Other | 53 | 17% |
Unknown | 70 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 56 | 18% |
Medicine and Dentistry | 50 | 16% |
Veterinary Science and Veterinary Medicine | 47 | 15% |
Biochemistry, Genetics and Molecular Biology | 24 | 8% |
Immunology and Microbiology | 20 | 6% |
Other | 32 | 10% |
Unknown | 90 | 28% |