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'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus

Overview of attention for article published in BMC Biology, June 2008
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Title
'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus
Published in
BMC Biology, June 2008
DOI 10.1186/1741-7007-6-25
Pubmed ID
Authors

Jacob G Bundy, Jasmin K Sidhu, Faisal Rana, David J Spurgeon, Claus Svendsen, Jodie F Wren, Stephen R Stürzenbaum, A John Morgan, Peter Kille

Abstract

New methods are needed for research into non-model organisms, to monitor the effects of toxic disruption at both the molecular and functional organism level. We exposed earthworms (Lumbricus rubellus Hoffmeister) to sub-lethal levels of copper (10-480 mg/kg soil) for 70 days as a real-world situation, and monitored both molecular (cDNA transcript microarrays and nuclear magnetic resonance-based metabolic profiling: metabolomics) and ecological/functional endpoints (reproduction rate and weight change, which have direct relevance to population-level impacts).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 134 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 2%
Canada 2 1%
United States 2 1%
Brazil 1 <1%
Australia 1 <1%
Russia 1 <1%
Portugal 1 <1%
Afghanistan 1 <1%
Poland 1 <1%
Other 0 0%
Unknown 121 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 34 25%
Student > Ph. D. Student 30 22%
Student > Master 12 9%
Student > Bachelor 9 7%
Student > Doctoral Student 8 6%
Other 25 19%
Unknown 16 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 53 40%
Environmental Science 26 19%
Biochemistry, Genetics and Molecular Biology 9 7%
Chemistry 8 6%
Medicine and Dentistry 4 3%
Other 9 7%
Unknown 25 19%