Title |
Possible role of ABO system in age-related diseases and longevity: a narrative review
|
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Published in |
Immunity & Ageing, November 2014
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DOI | 10.1186/1742-4933-11-16 |
Pubmed ID | |
Authors |
Claudia Rizzo, Calogero Caruso, Sonya Vasto |
Abstract |
ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with diverse and rapidly evolving pathogens. Accordingly, the different prevalence of ABO group genotypes among the populations has been demonstrated to be driven by malaria selection. In the similar manner, a particular ABO blood group may contribute to favour life-extension via biological mechanisms important for surviving or eluding serious disease. In this review, we will suggest the possible association of ABO group with age-related diseases and longevity taking into account the biological role of the ABO glycosyltransferases on some inflammatory mediators as adhesion molecules. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 36 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 29% |
Student > Ph. D. Student | 6 | 16% |
Student > Master | 5 | 13% |
Student > Postgraduate | 4 | 11% |
Other | 3 | 8% |
Other | 7 | 18% |
Unknown | 2 | 5% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 26% |
Agricultural and Biological Sciences | 10 | 26% |
Biochemistry, Genetics and Molecular Biology | 8 | 21% |
Immunology and Microbiology | 2 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 5 | 13% |