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Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI

Overview of attention for article published in Journal of Orthopaedic Surgery and Research, November 2017
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Title
Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI
Published in
Journal of Orthopaedic Surgery and Research, November 2017
DOI 10.1186/s13018-017-0669-x
Pubmed ID
Authors

Hui Li, Jia-zhi Yan, Yong-jie Chen, Wei-bo Kang, Jia-xi Huang

Abstract

Small animal models that can mimic degenerative disc disease (DDD) are commonly used to examine DDD progression. However, assessments such as histological studies and macroscopic measurements do not allow for longitudinal studies because they can only be completed after the animal is sacrificed. Dynamic contrast-enhanced MRI (DCE-MRI) may provide a reliable, non-invasive in vivo method for detecting the progression. The present study investigated the progression of changes in lumbar discs and the effect of endplate conditions on diffusion into the lumbar discs of aging sand rats after intravenous administration of gadolinium-containing contrast medium through the tail vein. Contrast enhancement was measured in the lumbar intervertebral discs on each image. The results were compared with those from conventional histological characterizations. T2-weighted images revealed that with aging, the shape of L3-L4, L4-L5, L5-L6, and L6-S1 nucleus pulposus (NP) became irregular, while the mean areas, signal intensities, and T2 values of the NP were significantly decreased. Each of the observed disc changes demonstrated a progressive increase in phase during 2-min scout scans. Post-contrast MRI showed impaired endplate nutritional diffusion to the disc with aging, enhancement was significantly greater in young animals than in old animals. Endplate calcification or sclerosis was histologically confirmed; histologic score was correlated with the age. We found the histological score of the endplate negatively corresponded to the DCE-MRI results. DCE-MRI studies offer a non-invasive in vivo method for investigating the progress of diffusion into the discs and the functional conditions of the endplate. We conclude that quantitative DCE-MRI can identify the severity of disc degeneration and efficiently reflect the progression of vertebral endplate changes in the aging sand rat lumbar spine via the NP contrast enhancement patterns.

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Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 6 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 1 17%
Student > Ph. D. Student 1 17%
Professor > Associate Professor 1 17%
Student > Postgraduate 1 17%
Unknown 2 33%
Readers by discipline Count As %
Unspecified 1 17%
Biochemistry, Genetics and Molecular Biology 1 17%
Agricultural and Biological Sciences 1 17%
Medicine and Dentistry 1 17%
Unknown 2 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 November 2017.
All research outputs
#9,693,610
of 12,122,714 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#400
of 584 outputs
Outputs of similar age
#205,253
of 282,980 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#18
of 31 outputs
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So far Altmetric has tracked 584 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.