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Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy

Overview of attention for article published in International Journal of Nanomedicine, October 2017
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

Mentioned by

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2 tweeters

Citations

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31 Dimensions

Readers on

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49 Mendeley
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Title
Supercritical carbon dioxide-developed silk fibroin nanoplatform for smart colon cancer therapy
Published in
International Journal of Nanomedicine, October 2017
DOI 10.2147/ijn.s145012
Pubmed ID
Authors

Maobin Xie, Dejun Fan, Yi Li, Xiaowen He, Xiaoming Chen, Yufeng Chen, Jixiang Zhu, Guibin Xu, Xiaojian Wu, Ping Lan

Abstract

To deliver insoluble natural compounds into colon cancer cells in a controlled fashion. Curcumin (CM)-silk fibroin (SF) nanoparticles (NPs) were prepared by solution-enhanced dispersion by supercritical CO2 (SEDS) (20 MPa pressure, 1:2 CM:SF ratio, 1% concentration), and their physicochemical properties, intracellular uptake efficiency, in vitro anticancer effect, toxicity, and mechanisms were evaluated and analyzed. CM-SF NPs (<100 nm) with controllable particle size were prepared by SEDS. CM-SF NPs had a time-dependent intracellular uptake ability, which led to an improved inhibition effect on colon cancer cells. Interestingly, the anticancer effect of CM-SF NPs was improved, while the side effect on normal human colon mucosal epithelial cells was reduced by a concentration of ~10 μg/mL. The anticancer mechanism involves cell-cycle arrest in the G0/G1 and G2/M phases in association with inducing apoptotic cells. The natural compound-loaded SF nanoplatform prepared by SEDS indicates promising colon cancer-therapy potential.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 49 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 20%
Student > Master 7 14%
Student > Bachelor 2 4%
Unspecified 2 4%
Professor 2 4%
Other 5 10%
Unknown 21 43%
Readers by discipline Count As %
Engineering 6 12%
Biochemistry, Genetics and Molecular Biology 5 10%
Chemistry 3 6%
Materials Science 3 6%
Agricultural and Biological Sciences 2 4%
Other 8 16%
Unknown 22 45%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 January 2022.
All research outputs
#14,217,957
of 22,792,160 outputs
Outputs from International Journal of Nanomedicine
#1,658
of 3,814 outputs
Outputs of similar age
#177,768
of 321,606 outputs
Outputs of similar age from International Journal of Nanomedicine
#33
of 85 outputs
Altmetric has tracked 22,792,160 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,814 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,606 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.