Title |
ROCK1 as a novel prognostic marker in vulvar cancer
|
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Published in |
BMC Cancer, November 2014
|
DOI | 10.1186/1471-2407-14-822 |
Pubmed ID | |
Authors |
Erica M Akagi, André M Lavorato-Rocha, Beatriz de Melo Maia, Iara S Rodrigues, Kátia C Carvalho, Monica M Stiepcich, Glauco Baiocchi, Yukie Sato-Kuwabara, Silvia R Rogatto, Fernando A Soares, Rafael M Rocha |
Abstract |
Vulvar carcinoma is an infrequent tumour, accounting for fewer than 3% of all malignant tumours that affect women, but its incidence is rising in the past few decades. In young women, the manifestation of the vulvar carcinoma is often linked to risk factors such as smoking and HPV infection, but most cases develop in women aged over 50 years through poorly understood genetic mechanisms. Rho-associated coiled-coil-containing protein kinase 1 (ROCK1) has been implicated in many cellular processes, but its function in vulvar cancer has never been examined. In this study, we aimed to determine the prognostic value of ROCK1 gene and protein analysis in vulvar squamous cell carcinoma (VSCC). |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 8 | 25% |
Student > Doctoral Student | 4 | 13% |
Student > Master | 4 | 13% |
Student > Bachelor | 3 | 9% |
Researcher | 3 | 9% |
Other | 4 | 13% |
Unknown | 6 | 19% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 16% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Computer Science | 1 | 3% |
Other | 4 | 13% |
Unknown | 8 | 25% |