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Attention Score in Context
| Title |
α-Glucosidase Inhibitory Activity from Ethyl Acetate Extract of Antidesma bunius (L.) Spreng Stem Bark Containing Triterpenoids
|
|---|---|
| Published in |
Pharmacognosy Magazine, November 2017
|
| DOI | 10.4103/pm.pm_25_17 |
| Pubmed ID | |
| Authors |
Marista Gilang Mauldina, Rani Sauriasari, Berna Elya |
| Abstract |
Buni (Antidesma bunius [L.] Spreng) has been used as a traditional antidiabetic agent in Asia. The mechanism of antidiabetic properties was studied in this study by determine its α-glucosidase inhibitory activity. Inhibition of α-glucosidase was performed in all fraction of Buni stem bark with acarbose and miglitol as standards. The half maximal inhibitory concentration (IC50) value of acarbose and miglitol was 5.75 and 59.76 μg/mL respectively while ethyl acetate (EtOAc) fraction was the most active fraction with IC50 of 19.33 μg/mL. Three isolates (B1, B2, and B3) were found in the EtOAc fraction and elucidated by infrared, 1hydrogen-nuclear magnetic resonance,13 carbon-nuclear magnetic resonance, and two-dimensional nuclear magnetic resonance. The chemical structures of the isolates were identified by the spectrum then compared with literature which concluded that B1 is friedelin, B2 is β-sitosterol, and B3 is betulinic acid. Inhibition of the α-glucosidase assay showed IC50 values of B1, B2, and B3 were 19.51, 49.85, and 18.49 μg/mL, respectively. α-Glucosidase inhibitory activity assay was performed in n-hexane, ethyl acetate (EtOAc), methanol fraction of Buni (Antidesma bunius (L.) Spreng) stem bark and miglitolEtOAc fraction from the liquid chromatography has the highest inhibitory activity against α-glucosidaseThe chemical structures of the isolates were identified by the spectrums infrared, 1hydrogen-nuclear magnetic resonance,13 carbon-nuclear magnetic resonance, and two-dimensional nuclear magnetic resonance, then compared with literature which concluded that B1 is friedelin, B2 is β-sitosterol, and B3 is betulinic acidBetulinic acid and friedelin showed the highest α-glucosidase inhibitory activity. Abbreviations used: IC50: Half maximal inhibitory concentration; H-NMR: Hydrogen-nuclear magnetic resonance; C-NMR: Carbon nuclear magnetic resonance; 2D-NMR: Two dimensional-nuclear magnetic resonance; EtOH: Ethanol; EtOAc: Ethyl acetate; MeOH: Methanol; CHCl3: Chloroform; DMSO: Dimethyl sulfoxide; EtF: Ethyl acetate fraction; Na2CO3: Sodium carbonate; IR: Infrared; TGR5: Transmembrane G protein-coupled receptor 5; EC50: Half maximal effective concentration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 7 | 23% |
| Student > Master | 4 | 13% |
| Lecturer | 3 | 10% |
| Researcher | 3 | 10% |
| Student > Ph. D. Student | 3 | 10% |
| Other | 1 | 3% |
| Unknown | 10 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 19% |
| Chemistry | 3 | 10% |
| Medicine and Dentistry | 3 | 10% |
| Agricultural and Biological Sciences | 3 | 10% |
| Environmental Science | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 11 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Pharmacognosy Magazine
#281
of 516 outputs
Outputs of similar age
#296,044
of 336,988 outputs
Outputs of similar age from Pharmacognosy Magazine
#16
of 35 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 516 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,988 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.