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Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review

Overview of attention for article published in Acta Dermato-Venereologica, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

dimensions_citation
54 Dimensions

Readers on

mendeley
48 Mendeley
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Title
Effective Strategies for the Management of Pyoderma Gangrenosum: A Comprehensive Review
Published in
Acta Dermato-Venereologica, January 2015
DOI 10.2340/00015555-2008
Pubmed ID
Authors

F Patel, S Fitzmaurice, C Duong, Y He, J Fergus, S Raychaudhuri, M Garcia, E Maverakis

Abstract

Pyoderma gangrenosum (PG) is an inflammatory disease characterized by painful skin ulcerations with undermined and erythematous borders. The etiology of PG is not well understood, but it is generally considered to be an aberrant immune response characterized by a dermal neutrophilc infiltrate. Given the existence of only a few PG clinical trials, treatment options are largely based upon anecdotal data and small case studies. In addition to classic immunosuppressive medications, PG has been reported to respond well to the anti-TNF agents, infliximab, etanercept, adalimumab. Newer biologics such as ustekinumab (anti-IL-23), ixekizumab (anti-IL-17) and brodalumab (anti-IL-17R) are promising given the effect of IL-17 on neutrophil migration. However, the effectiveness of these newer agents remains to be rigorously evaluated. Multi-drug regimens have not been well described in the literature but are an excellent alternative for patients with refractory disease. Herein, we provide a comprehensive review of the pathophysiology of PG and of the different treatments available for managing PG patients, including the theoretical benefit of initiating multidrug regimens. We also provide one possible treatment algorithm for patients with refractory disease and give examples of refractory PG cases successfully treated with multidrug regimens.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 21%
Student > Doctoral Student 9 19%
Student > Ph. D. Student 6 13%
Professor > Associate Professor 4 8%
Other 4 8%
Other 13 27%
Unknown 2 4%
Readers by discipline Count As %
Medicine and Dentistry 30 63%
Biochemistry, Genetics and Molecular Biology 3 6%
Immunology and Microbiology 3 6%
Agricultural and Biological Sciences 2 4%
Nursing and Health Professions 2 4%
Other 4 8%
Unknown 4 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2015.
All research outputs
#3,322,264
of 12,367,026 outputs
Outputs from Acta Dermato-Venereologica
#131
of 918 outputs
Outputs of similar age
#57,697
of 225,694 outputs
Outputs of similar age from Acta Dermato-Venereologica
#1
of 7 outputs
Altmetric has tracked 12,367,026 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 918 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,694 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them