Title |
The Anti-allergic Cromones: Past, Present, and Future
|
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Published in |
Frontiers in Pharmacology, November 2017
|
DOI | 10.3389/fphar.2017.00827 |
Pubmed ID | |
Authors |
Ajantha Sinniah, Samia Yazid, Roderick J. Flower |
Abstract |
The anti-allergic cromones were originally synthesized in the 1960s by Fisons Plc, and the first drug to emerge from this program, disodium cromoglycate was subsequently marketed for the treatment of asthma and other allergic conditions. Whilst early studies demonstrated that the ability of the cromones to prevent allergic reactions was due to their 'mast cell stabilizing' properties, the exact pharmacological mechanism by which this occurred, remained a mystery. Here, we briefly review the history of these drugs, recount some aspects of their pharmacology, and discuss two new explanations for their unique actions. We further suggest how these findings could be used to predict further uses for the cromones. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Australia | 2 | 40% |
United States | 1 | 20% |
Switzerland | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 60% |
Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 45 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 18% |
Researcher | 6 | 13% |
Student > Master | 6 | 13% |
Student > Bachelor | 4 | 9% |
Other | 3 | 7% |
Other | 4 | 9% |
Unknown | 14 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 13% |
Medicine and Dentistry | 6 | 13% |
Chemistry | 5 | 11% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Agricultural and Biological Sciences | 3 | 7% |
Other | 7 | 16% |
Unknown | 14 | 31% |