Title |
Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies
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Published in |
Journal of Neuropathology and Experimental Neurology, November 2017
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DOI | 10.1093/jnen/nlx101 |
Pubmed ID | |
Authors |
Kimbra Kenney, Diego Iacono, Brian L Edlow, Douglas I Katz, Ramon Diaz-Arrastia, Kristen Dams-O’Connor, Daniel H Daneshvar, Allison Stevens, Allison L Moreau, Lee S Tirrell, Ani Varjabedian, Anastasia Yendiki, Andre van der Kouwe, Azma Mareyam, Jennifer A McNab, Wayne A Gordon, Bruce Fischl, Ann C McKee, Daniel P Perl |
Abstract |
We report the clinical, neuroimaging, and neuropathologic characteristics of 2 patients who developed early onset dementia after a moderate-severe traumatic brain injury (TBI). Neuropathological evaluation revealed abundant β-amyloid neuritic and cored plaques, diffuse β-amyloid plaques, and frequent hyperphosphorylated-tau neurofibrillary tangles (NFT) involving much of the cortex, including insula and mammillary bodies in both cases. Case 1 additionally showed NFTs in both the superficial and deep cortical layers, occasional perivascular and depth-of-sulci NFTs, and parietal white matter rarefaction, which corresponded with decreased parietal fiber tracts observed on ex vivo MRI. Case 2 additionally showed NFT predominance in the superficial layers of the cortex, hypothalamus and brainstem, diffuse Lewy bodies in the cortex, amygdala and brainstem, and intraneuronal TDP-43 inclusions. The neuropathologic diagnoses were atypical Alzheimer disease (AD) with features of chronic traumatic encephalopathy and white matter loss (Case 1), and atypical AD, dementia with Lewy bodies and coexistent TDP-43 pathology (Case 2). These findings support an epidemiological association between TBI and dementia and further characterize the variety of misfolded proteins that may accumulate after TBI. Analyses with comprehensive clinical, imaging, genetic, and neuropathological data are required to characterize the full clinicopathological spectrum associated with dementias occurring after moderate-severe TBI. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 6 | 46% |
Australia | 2 | 15% |
Chile | 1 | 8% |
Unknown | 4 | 31% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 11 | 85% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Scientists | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 119 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 14 | 12% |
Student > Ph. D. Student | 10 | 8% |
Student > Master | 10 | 8% |
Student > Doctoral Student | 9 | 8% |
Professor | 8 | 7% |
Other | 26 | 22% |
Unknown | 42 | 35% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 26 | 22% |
Medicine and Dentistry | 19 | 16% |
Psychology | 6 | 5% |
Biochemistry, Genetics and Molecular Biology | 5 | 4% |
Agricultural and Biological Sciences | 4 | 3% |
Other | 12 | 10% |
Unknown | 47 | 39% |