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Two dopaminergic genes, DRD4 and SLC6A3, are associated with body mass index in a Colombian sample of young adults

Overview of attention for article published in Archives of Physiology & Biochemistry, November 2017
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Title
Two dopaminergic genes, DRD4 and SLC6A3, are associated with body mass index in a Colombian sample of young adults
Published in
Archives of Physiology & Biochemistry, November 2017
DOI 10.1080/13813455.2017.1401643
Pubmed ID
Authors

Yeimy González-Giraldo, Martha L. Trujillo, Diego A. Forero

Abstract

Obesity is becoming an epidemic in Latin American countries. Genetic analyses of endophenotypes for obesity, such as body mass index (BMI), are quite useful for research. In this study, we analysed two functional polymorphisms in the dopamine receptor 4 (DRD4) and dopamine transporter (SLC6A3) genes. A sample of 232 Colombian young subjects were recruited and evaluated for BMI. Two functional polymorphisms in the DRD4 and SLC6A3 and genes were genotyped by PCR and electrophoresis. A significant association was found between BMI and the polymorphisms in DRD4 and SLC6A3 genes. DRD4 4/4 genotype was associated with a lower mean BMI and SLC6A3 10/10 genotype was associated with a higher mean BMI. Our work provides additional novel findings about the association of dopaminergic genes with BMI in healthy young adults. In addition, our study is one the first analyses of candidate genes for BMI in Latin American samples.

X Demographics

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 21%
Student > Bachelor 3 16%
Student > Doctoral Student 2 11%
Researcher 2 11%
Librarian 1 5%
Other 4 21%
Unknown 3 16%
Readers by discipline Count As %
Medicine and Dentistry 5 26%
Biochemistry, Genetics and Molecular Biology 4 21%
Social Sciences 2 11%
Sports and Recreations 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 2 11%
Unknown 4 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2017.
All research outputs
#16,725,651
of 25,382,440 outputs
Outputs from Archives of Physiology & Biochemistry
#211
of 501 outputs
Outputs of similar age
#192,860
of 318,891 outputs
Outputs of similar age from Archives of Physiology & Biochemistry
#1
of 10 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 501 research outputs from this source. They receive a mean Attention Score of 2.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,891 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them