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Saliva as a sampling source for the detection of leukemic fusion transcripts

Overview of attention for article published in Journal of Translational Medicine, November 2014
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Average Attention Score compared to outputs of the same age and source

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2 tweeters

Citations

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2 Dimensions

Readers on

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13 Mendeley
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Title
Saliva as a sampling source for the detection of leukemic fusion transcripts
Published in
Journal of Translational Medicine, November 2014
DOI 10.1186/s12967-014-0321-z
Pubmed ID
Authors

Dongmei Chen, Najie Song, Runfang Ni, Jiangning Zhao, Jiasheng Hu, Quanyi Lu, Qingge Li

Abstract

BackgroundSaliva has long been used as a sampling source for clinical diagnosis of oral disease such as oral squamous cell carcinoma, or therapeutic drug monitoring. The aims of this study was to ascertain if saliva RNA could be stored at room temperature and to study if saliva could be a convenient source for fusion transcripts in leukemic patients.MethodsThis is a cross-sectional diagnostic study. We first developed a Saliva RNA tube for stable storage of whole saliva RNA at room temperature. Then we detected the leukemic fusions in the whole saliva from seven leukemic patients and twenty healthy volunteers, and compared with the results obtained from the bone marrow of the patients.ResultsHuman gene transcripts could be reproducibly detected in the whole saliva for at least four weeks when stored in the developed composition at room temperature. Concordant results of the fusion transcripts were obtained between the saliva and the bone marrow in the seven leukemic patients and no fusions were detected in the healthy controls.ConclusionsThe results support our hypothesis that human whole saliva could be a reliable and convenient sampling source for the detection of leukemic fusions.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 31%
Student > Ph. D. Student 3 23%
Student > Bachelor 2 15%
Other 2 15%
Professor 1 8%
Other 1 8%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 38%
Agricultural and Biological Sciences 4 31%
Medicine and Dentistry 2 15%
Neuroscience 1 8%
Physics and Astronomy 1 8%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2014.
All research outputs
#2,041,229
of 4,570,588 outputs
Outputs from Journal of Translational Medicine
#473
of 1,285 outputs
Outputs of similar age
#57,169
of 140,223 outputs
Outputs of similar age from Journal of Translational Medicine
#32
of 75 outputs
Altmetric has tracked 4,570,588 research outputs across all sources so far. This one has received more attention than most of these and is in the 52nd percentile.
So far Altmetric has tracked 1,285 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,223 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.