Title |
Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses
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Published in |
BMC Cancer, November 2014
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DOI | 10.1186/1471-2407-14-857 |
Pubmed ID | |
Authors |
Lin Jiang, Cécile Campagne, Elisabeth Sundström, Pedro Sousa, Saima Imran, Monika Seltenhammer, Gerli Pielberg, Mats J Olsson, Giorgia Egidy, Leif Andersson, Anna Golovko |
Abstract |
Constitutive activation of the ERK pathway, occurring in the vast majority of melanocytic neoplasms, has a pivotal role in melanoma development. Different mechanisms underlie this activation in different tumour settings. The Grey phenotype in horses, caused by a 4.6 kb duplication in intron 6 of Syntaxin 17 (STX17), is associated with a very high incidence of cutaneous melanoma, but the molecular mechanism behind the melanomagenesis remains unknown. Here, we investigated the involvement of the ERK pathway in melanoma development in Grey horses. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 24% |
Student > Ph. D. Student | 5 | 12% |
Student > Master | 5 | 12% |
Student > Bachelor | 3 | 7% |
Student > Postgraduate | 2 | 5% |
Other | 5 | 12% |
Unknown | 11 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 24% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Veterinary Science and Veterinary Medicine | 6 | 15% |
Medicine and Dentistry | 3 | 7% |
Unspecified | 1 | 2% |
Other | 4 | 10% |
Unknown | 11 | 27% |