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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells
|
|---|---|
| Published in |
Scientific Reports, November 2014
|
| DOI | 10.1038/srep07144 |
| Pubmed ID | |
| Authors |
Dominik Duscher, Robert C. Rennert, Michael Januszyk, Ersilia Anghel, Zeshaan N. Maan, Alexander J. Whittam, Marcelina G. Perez, Revanth Kosaraju, Michael S. Hu, Graham G. Walmsley, David Atashroo, Sacha Khong, Atul J. Butte, Geoffrey C. Gurtner |
| Abstract |
Advanced age is associated with an increased risk of vascular morbidity, attributable in part to impairments in new blood vessel formation. Mesenchymal stem cells (MSCs) have previously been shown to play an important role in neovascularization and deficiencies in these cells have been described in aged patients. Here we utilize single cell transcriptional analysis to determine the effect of aging on MSC population dynamics. We identify an age-related depletion of a subpopulation of MSCs characterized by a pro-vascular transcriptional profile. Supporting this finding, we demonstrate that aged MSCs are also significantly compromised in their ability to support vascular network formation in vitro and in vivo. Finally, aged MSCs are unable to rescue age-associated impairments in cutaneous wound healing. Taken together, these data suggest that age-related changes in MSC population dynamics result in impaired therapeutic potential of aged progenitor cells. These findings have critical implications for therapeutic cell source decisions (autologous versus allogeneic) and indicate the necessity of strategies to improve functionality of aged MSCs. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 64% |
| Russia | 1 | 9% |
| Netherlands | 1 | 9% |
| Unknown | 2 | 18% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 73% |
| Science communicators (journalists, bloggers, editors) | 2 | 18% |
| Scientists | 1 | 9% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 21% |
| Researcher | 20 | 17% |
| Student > Master | 11 | 9% |
| Professor > Associate Professor | 7 | 6% |
| Other | 7 | 6% |
| Other | 21 | 17% |
| Unknown | 29 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 23% |
| Medicine and Dentistry | 24 | 20% |
| Biochemistry, Genetics and Molecular Biology | 20 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Engineering | 4 | 3% |
| Other | 8 | 7% |
| Unknown | 33 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2020.
All research outputs
#3,283,867
of 25,144,989 outputs
Outputs from Scientific Reports
#27,999
of 138,166 outputs
Outputs of similar age
#44,595
of 374,875 outputs
Outputs of similar age from Scientific Reports
#139
of 815 outputs
Altmetric has tracked 25,144,989 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 138,166 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 374,875 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 815 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.