Title |
The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade
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Published in |
Pathology & Oncology Research, October 2014
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DOI | 10.1007/s12253-014-9835-1 |
Pubmed ID | |
Authors |
Shakti Ranjan Satapathy, Purusottam Mohapatra, Dipon Das, Sumit Siddharth, Chanakya Nath Kundu |
Abstract |
Here, we report the p53 dependent mitochondria-mediated apoptotic mechanism of plant derived silver-nanoparticle (PD-AgNPs) in colorectal cancer cells (CRCs). PD-AgNPs was synthesized by reduction of AgNO3 with leaf extract of a medicinal plant periwinkle and characterized. Uptake of PD-AgNPs (ξ - 2.52 ± 4.31 mV) in HCT116 cells was 3 fold higher in comparison to synthetic AgNPs (ξ +2.293 ± 5.1 mV). A dose dependent increase in ROS production, activated JNK and decreased mitochondrial membrane potential (MMP) were noted in HCT116 but not in HCT116 p53 (-/-) cells after PD-AgNP exposure. PD-AgNP-mediated apoptosis in CRCs is a p53 dependent process involving ROS and JNK cascade. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 11 | 37% |
Student > Ph. D. Student | 8 | 27% |
Other | 2 | 7% |
Professor | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 3 | 10% |
Unknown | 2 | 7% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 6 | 20% |
Biochemistry, Genetics and Molecular Biology | 5 | 17% |
Immunology and Microbiology | 3 | 10% |
Environmental Science | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Other | 8 | 27% |
Unknown | 4 | 13% |