Title |
Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects
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Published in |
European Journal of Nuclear Medicine and Molecular Imaging, November 2014
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DOI | 10.1007/s00259-014-2955-8 |
Pubmed ID | |
Authors |
Andrea Varrone, Vesa Oikonen, Anton Forsberg, Juho Joutsa, Akihiro Takano, Olof Solin, Merja Haaparanta-Solin, Sangram Nag, Ryuji Nakao, Nabil Al-Tawil, Lisa A. Wells, Eugenii A. Rabiner, Ray Valencia, Marcus Schultze-Mosgau, Andrea Thiele, Sonja Vollmer, Thomas Dyrks, Lutz Lehmann, Tobias Heinrich, Anja Hoffmann, Agneta Nordberg, Christer Halldin, Juha O. Rinne |
Abstract |
Imaging of the 18-kDa translocator protein (TSPO) is a potential tool for examining microglial activation and neuroinflammation in early Alzheimer's disease (AD). [(18)F]FEMPA is a novel high-affinity second-generation TSPO radioligand that has displayed suitable pharmacokinetic properties in preclinical studies. The aims of this study were to quantify the binding of [(18)F]FEMPA to TSPO in AD patients and controls and to investigate whether higher [(18)F]FEMPA binding in AD patients than in controls could be detected in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Finland | 1 | 1% |
Germany | 1 | 1% |
Unknown | 75 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 25% |
Student > Ph. D. Student | 13 | 17% |
Student > Master | 9 | 12% |
Other | 5 | 6% |
Student > Doctoral Student | 3 | 4% |
Other | 11 | 14% |
Unknown | 17 | 22% |
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Medicine and Dentistry | 25 | 32% |
Neuroscience | 11 | 14% |
Chemistry | 4 | 5% |
Agricultural and Biological Sciences | 3 | 4% |
Psychology | 2 | 3% |
Other | 5 | 6% |
Unknown | 27 | 35% |