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Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects

Overview of attention for article published in European Journal of Nuclear Medicine and Molecular Imaging, November 2014
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Title
Positron emission tomography imaging of the 18-kDa translocator protein (TSPO) with [18F]FEMPA in Alzheimer’s disease patients and control subjects
Published in
European Journal of Nuclear Medicine and Molecular Imaging, November 2014
DOI 10.1007/s00259-014-2955-8
Pubmed ID
Authors

Andrea Varrone, Vesa Oikonen, Anton Forsberg, Juho Joutsa, Akihiro Takano, Olof Solin, Merja Haaparanta-Solin, Sangram Nag, Ryuji Nakao, Nabil Al-Tawil, Lisa A. Wells, Eugenii A. Rabiner, Ray Valencia, Marcus Schultze-Mosgau, Andrea Thiele, Sonja Vollmer, Thomas Dyrks, Lutz Lehmann, Tobias Heinrich, Anja Hoffmann, Agneta Nordberg, Christer Halldin, Juha O. Rinne

Abstract

Imaging of the 18-kDa translocator protein (TSPO) is a potential tool for examining microglial activation and neuroinflammation in early Alzheimer's disease (AD). [(18)F]FEMPA is a novel high-affinity second-generation TSPO radioligand that has displayed suitable pharmacokinetic properties in preclinical studies. The aims of this study were to quantify the binding of [(18)F]FEMPA to TSPO in AD patients and controls and to investigate whether higher [(18)F]FEMPA binding in AD patients than in controls could be detected in vivo.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Finland 1 1%
Germany 1 1%
Unknown 75 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 19 25%
Student > Ph. D. Student 13 17%
Student > Master 9 12%
Other 5 6%
Student > Doctoral Student 3 4%
Other 11 14%
Unknown 17 22%
Readers by discipline Count As %
Medicine and Dentistry 25 32%
Neuroscience 11 14%
Chemistry 4 5%
Agricultural and Biological Sciences 3 4%
Psychology 2 3%
Other 5 6%
Unknown 27 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2014.
All research outputs
#16,042,980
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#1,980
of 3,083 outputs
Outputs of similar age
#219,442
of 366,357 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#17
of 31 outputs
Altmetric has tracked 23,806,312 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,083 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 366,357 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.