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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neurotrophins are expressed in giant cell arteritis lesions and may contribute to vascular remodeling
|
|---|---|
| Published in |
Arthritis Research & Therapy, November 2014
|
| DOI | 10.1186/s13075-014-0487-z |
| Pubmed ID | |
| Authors |
Kim Heang Ly, Alexis Régent, Elsa Molina, Sofiane Saada, Philippe Sindou, Claire Le-Jeunne, Antoine Brézin, Véronique Witko-Sarsat, François Labrousse, Pierre-Yves Robert, Philippe Bertin, Jean-Louis Bourges, Anne-Laure Fauchais, Elisabeth Vidal, Luc Mouthon, Marie-Odile Jauberteau |
| Abstract |
IntroductionGiant cell arteritis (GCA) is characterized by intimal hyperplasia leading to ischemic manifestations that involve large vessels. Neurotrophins (NTs) and their receptors (NTRs) are protein factors for growth, differentiation and survival of neurons. They are also involved in the migration of vascular smooth muscle cells (VSMCs). Our aim was to investigate whether NTs and NTRs are involved in vascular remodeling of GCA.MethodsWe included consecutive patients who underwent a temporal-artery biopsy for suspected GCA. We developed an enzymatic digestion method to obtain VSMCs from smooth muscle cells in GCA patients and controls. Neurotrophin protein and gene expression and functional assays were studied from these VSMC. Neurotrophin expression was also analysed by immunohistochemistry in GCA patients and controls.ResultsWhereas temporal arteries of both GCA patients (n =22) and controls (n =21) expressed nerve-growth factor (NGF), brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) and sortilin, immunostaining was more intense in GCA patients, especially in the media and intima, while neurotrophin-3 (NT-3) and P75 receptor (P75NTR) were only detected in TA from GCA patients. Expression of TrkB, a BDNF receptor, was higher in GCA patients with ischemic complications. Serum NGF was significantly higher in GCA patients (n =28) vs controls (n =48), whereas no significant difference was found for BDNF and NT-3. NGF and BDNF enhanced GCA- derived temporal-artery VSMCs proliferation and BDNF facilitated migration of temporal-artery VSMCs in patients with GCA compared to controls.ConclusionOur results suggest that NTs and NTRs are involved in vascular remodeling of GCA. In GCA-derived temporal-artery VSMC, NGF promoted proliferation and BDNF enhanced migration by binding to TrkB and p75NTR receptors. Further experiments are needed on a larger number of VSMC samples to confirm these results. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 20% |
| Student > Ph. D. Student | 7 | 20% |
| Other | 3 | 9% |
| Student > Doctoral Student | 3 | 9% |
| Professor > Associate Professor | 3 | 9% |
| Other | 3 | 9% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 26% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
| Biochemistry, Genetics and Molecular Biology | 4 | 11% |
| Neuroscience | 2 | 6% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 4 | 11% |
| Unknown | 11 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2014.
All research outputs
#19,944,994
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#2,814
of 3,381 outputs
Outputs of similar age
#260,124
of 369,496 outputs
Outputs of similar age from Arthritis Research & Therapy
#42
of 55 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,496 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.