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X Demographics
Mendeley readers
Attention Score in Context
| Title |
NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons
|
|---|---|
| Published in |
Neuron, November 2014
|
| DOI | 10.1016/j.neuron.2014.10.040 |
| Pubmed ID | |
| Authors |
Amelia Stanco, Ramón Pla, Daniel Vogt, Yiran Chen, Shyamali Mandal, Jamie Walker, Robert F. Hunt, Susan Lindtner, Carolyn A. Erdman, Andrew A. Pieper, Steven P. Hamilton, Duan Xu, Scott C. Baraban, John L.R. Rubenstein |
| Abstract |
Little is known about genetic mechanisms that regulate the ratio of cortical excitatory and inhibitory neurons. We show that NPAS1 and NPAS3 transcription factors (TFs) are expressed in progenitor domains of the mouse basal ganglia (subpallium, MGE, and CGE). NPAS1(-/-) mutants had increased proliferation, ERK signaling, and expression of Arx in the MGE and CGE. NPAS1(-/-) mutants also had increased neocortical inhibition (sIPSC and mIPSC) and generated an excess of somatostatin(+) (SST) (MGE-derived) and vasoactive intestinal polypeptide(+) (VIP) (CGE-derived) neocortical interneurons, but had a normal density of parvalbumin(+) (PV) (MGE-derived) interneurons. In contrast, NPAS3(-/-) mutants showed decreased proliferation and ERK signaling in progenitors of the ganglionic eminences and had fewer SST(+) and VIP(+) interneurons. NPAS1 repressed activity of an Arx enhancer, and Arx overexpression resulted in increased proliferation of CGE progenitors. These results provide insights into genetic regulation of cortical interneuron numbers and cortical inhibitory tone. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Scientists | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 138 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 1% |
| United Kingdom | 1 | <1% |
| Sweden | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 133 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 45 | 33% |
| Student > Ph. D. Student | 29 | 21% |
| Student > Bachelor | 13 | 9% |
| Professor > Associate Professor | 9 | 7% |
| Other | 8 | 6% |
| Other | 24 | 17% |
| Unknown | 10 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 52 | 38% |
| Agricultural and Biological Sciences | 31 | 22% |
| Biochemistry, Genetics and Molecular Biology | 15 | 11% |
| Medicine and Dentistry | 9 | 7% |
| Engineering | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 18 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 July 2022.
All research outputs
#7,688,662
of 25,373,627 outputs
Outputs from Neuron
#6,309
of 9,543 outputs
Outputs of similar age
#98,496
of 369,141 outputs
Outputs of similar age from Neuron
#94
of 124 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 9,543 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 369,141 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 124 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.