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Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease

Overview of attention for article published in PLOS ONE, November 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
50 Dimensions

Readers on

mendeley
90 Mendeley
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Title
Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease
Published in
PLOS ONE, November 2009
DOI 10.1371/journal.pone.0007931
Pubmed ID
Authors

Antje Willuweit, Joachim Velden, Robert Godemann, Andre Manook, Fritz Jetzek, Hartmut Tintrup, Gunther Kauselmann, Branko Zevnik, Gjermund Henriksen, Alexander Drzezga, Johannes Pohlner, Michael Schoor, John A. Kemp, Heinz von der Kammer

Abstract

Transgenic mice expressing mutated amyloid precursor protein (APP) and presenilin (PS)-1 or -2 have been successfully used to model cerebral beta-amyloidosis, one of the characteristic hallmarks of Alzheimer's disease (AD) pathology. However, the use of many transgenic lines is limited by premature death, low breeding efficiencies and late onset and high inter-animal variability of the pathology, creating a need for improved animal models. Here we describe the detailed characterization of a new homozygous double-transgenic mouse line that addresses most of these issues.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 1%
Germany 1 1%
Unknown 88 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 26%
Student > Ph. D. Student 15 17%
Student > Master 10 11%
Professor > Associate Professor 6 7%
Student > Doctoral Student 6 7%
Other 16 18%
Unknown 14 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 27%
Medicine and Dentistry 16 18%
Neuroscience 9 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Biochemistry, Genetics and Molecular Biology 3 3%
Other 10 11%
Unknown 23 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2014.
All research outputs
#5,667,507
of 22,771,140 outputs
Outputs from PLOS ONE
#68,997
of 194,253 outputs
Outputs of similar age
#36,570
of 165,763 outputs
Outputs of similar age from PLOS ONE
#225
of 535 outputs
Altmetric has tracked 22,771,140 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 194,253 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 165,763 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 535 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.