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Orthogonal muscle fibres have different instructive roles in planarian regeneration

Overview of attention for article published in Nature, November 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (55th percentile)

Citations

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84 Mendeley
Title
Orthogonal muscle fibres have different instructive roles in planarian regeneration
Published in
Nature, November 2017
DOI 10.1038/nature24660
Pubmed ID
Authors

M. Lucila Scimone, Lauren E. Cote, Peter W. Reddien

Abstract

The ability to regenerate missing body parts exists throughout the animal kingdom. Positional information is crucial for regeneration, but how it is harboured and used by differentiated tissues is poorly understood. In planarians, positional information has been identified from study of phenotypes caused by RNA interference in which the wrong tissues are regenerated. For example, inhibition of the Wnt signalling pathway leads to regeneration of heads in place of tails. Characterization of these phenotypes has led to the identification of position control genes (PCGs)-genes that are expressed in a constitutive and regional manner and are associated with patterning. Most PCGs are expressed within planarian muscle; however, how muscle is specified and how different muscle subsets affect regeneration is unknown. Here we show that different muscle fibres have distinct regulatory roles during regeneration in the planarian Schmidtea mediterranea. myoD is required for formation of a specific muscle cell subset: the longitudinal fibres, oriented along the anterior-posterior axis. Loss of longitudinal fibres led to complete regeneration failure because of defects in regeneration initiation. A different transcription factor-encoding gene, nkx1-1, is required for the formation of circular fibres, oriented along the medial-lateral axis. Loss of circular fibres led to a bifurcated anterior-posterior axis with fused heads forming in single anterior blastemas. Whereas muscle is often viewed as a strictly contractile tissue, these findings reveal that different muscle types have distinct and specific regulatory roles in wound signalling and patterning to enable regeneration.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 84 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 27%
Researcher 18 21%
Unspecified 10 12%
Student > Master 10 12%
Student > Bachelor 6 7%
Other 17 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 35 42%
Biochemistry, Genetics and Molecular Biology 26 31%
Unspecified 12 14%
Engineering 3 4%
Neuroscience 2 2%
Other 6 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 116. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2018.
All research outputs
#120,405
of 12,819,713 outputs
Outputs from Nature
#10,276
of 66,965 outputs
Outputs of similar age
#6,703
of 387,164 outputs
Outputs of similar age from Nature
#296
of 667 outputs
Altmetric has tracked 12,819,713 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 66,965 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 73.5. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,164 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 667 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.