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A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

Overview of attention for article published in Nature, November 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
twitter
296 tweeters
facebook
8 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor

Citations

dimensions_citation
81 Dimensions

Readers on

mendeley
434 Mendeley
citeulike
2 CiteULike
Title
A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites
Published in
Nature, November 2017
DOI 10.1038/nature24661
Pubmed ID
Authors

Dylan Dodd, Matthew H. Spitzer, William Van Treuren, Bryan D. Merrill, Andrew J. Hryckowian, Steven K. Higginbottom, Anthony Le, Tina M. Cowan, Garry P. Nolan, Michael A. Fischbach, Justin L. Sonnenburg

Abstract

The human gut microbiota produces dozens of metabolites that accumulate in the bloodstream, where they can have systemic effects on the host. Although these small molecules commonly reach concentrations similar to those achieved by pharmaceutical agents, remarkably little is known about the microbial metabolic pathways that produce them. Here we use a combination of genetics and metabolic profiling to characterize a pathway from the gut symbiont Clostridium sporogenes that generates aromatic amino acid metabolites. Our results reveal that this pathway produces twelve compounds, nine of which are known to accumulate in host serum. All three aromatic amino acids (tryptophan, phenylalanine and tyrosine) serve as substrates for the pathway, and it involves branching and alternative reductases for specific intermediates. By genetically manipulating C. sporogenes, we modulate serum levels of these metabolites in gnotobiotic mice, and show that in turn this affects intestinal permeability and systemic immunity. This work has the potential to provide the basis of a systematic effort to engineer the molecular output of the gut bacterial community.

Twitter Demographics

The data shown below were collected from the profiles of 296 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 434 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 434 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 112 26%
Researcher 99 23%
Unspecified 56 13%
Student > Master 47 11%
Student > Bachelor 33 8%
Other 71 16%
Unknown 16 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 127 29%
Biochemistry, Genetics and Molecular Biology 88 20%
Unspecified 64 15%
Immunology and Microbiology 57 13%
Medicine and Dentistry 28 6%
Other 54 12%
Unknown 16 4%

Attention Score in Context

This research output has an Altmetric Attention Score of 175. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2018.
All research outputs
#75,886
of 13,223,530 outputs
Outputs from Nature
#7,652
of 68,911 outputs
Outputs of similar age
#4,060
of 387,399 outputs
Outputs of similar age from Nature
#218
of 675 outputs
Altmetric has tracked 13,223,530 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 68,911 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 75.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,399 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 675 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.