Title |
Cytokines from the pig conceptus: roles in conceptus development in pigs
|
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Published in |
Journal of Animal Science and Biotechnology, November 2014
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DOI | 10.1186/2049-1891-5-51 |
Pubmed ID | |
Authors |
Rodney D Geisert, Matthew C Lucy, Jeffrey J Whyte, Jason W Ross, Daniel J Mathew |
Abstract |
Establishment of pregnancy in pigs involves maintaining progesterone secretion from the corpora lutea in addition to regulating a sensitive interplay between the maternal immune system and attachment of the rapidly expanding trophoblast for nutrient absorption. The peri-implantation period of rapid trophoblastic elongation followed by attachment to the maternal uterine endometrium is critical for establishing a sufficient placental-uterine interface for subsequent nutrient transport for fetal survival to term, but is also marked by the required conceptus release of factors involved with stimulating uterine secretion of histotroph and modulation of the maternal immune system. Many endometrial genes activated by the conceptus secretory factors stimulate a tightly controlled proinflammatory response within the uterus. A number of the cytokines released by the elongating conceptuses stimulate inducible transcription factors such as nuclear factor kappa B (NFKB) potentially regulating the maternal uterine proinflammatory and immune response. This review will establish the current knowledge for the role of conceptus cytokine production and release in early development and establishment of pregnancy in the pig. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Peru | 1 | 1% |
Unknown | 67 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 19% |
Student > Ph. D. Student | 12 | 18% |
Student > Master | 8 | 12% |
Student > Doctoral Student | 7 | 10% |
Professor | 4 | 6% |
Other | 5 | 7% |
Unknown | 19 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 25 | 37% |
Veterinary Science and Veterinary Medicine | 7 | 10% |
Biochemistry, Genetics and Molecular Biology | 4 | 6% |
Immunology and Microbiology | 4 | 6% |
Medicine and Dentistry | 2 | 3% |
Other | 2 | 3% |
Unknown | 24 | 35% |