Title |
Overexpression of E2F1 in human gastric carcinoma is involved in anti-cancer drug resistance
|
---|---|
Published in |
BMC Cancer, December 2014
|
DOI | 10.1186/1471-2407-14-904 |
Pubmed ID | |
Authors |
Lin-Hai Yan, Wei-Yuan Wei, Wen-Long Cao, Xiao-Shi Zhang, Yu-Bo Xie, Qiang Xiao |
Abstract |
Routine chemotherapy often cannot achieve good therapeutic effects because of multidrug resistance (MDR). MDR is frequently caused by the elevated expression of the MDR1 gene encoding P-glycoprotein (P-gp). E2F1 is a frequently overexpressed protein in human tumor cells that increases the activity of the MDR1 promoter, resulting in higher P-gp levels. The upregulation of P-gp might contribute to the survival of tumor cells during chemotherapy. E2F1 confers anticancer drug resistance; however, we speculate whether E2F1 affects MDR through other pathways. This study investigated the possible involvement of E2F1 in anticancer drug resistance of gastric carcinoma in vitro and in vivo. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 7 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 26% |
Student > Ph. D. Student | 7 | 21% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Professor > Associate Professor | 2 | 6% |
Other | 3 | 9% |
Unknown | 7 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 10 | 29% |
Agricultural and Biological Sciences | 8 | 24% |
Medicine and Dentistry | 4 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Decision Sciences | 1 | 3% |
Other | 0 | 0% |
Unknown | 9 | 26% |