Title |
Evaluation of clonal origin of malignant mesothelioma
|
---|---|
Published in |
Journal of Translational Medicine, December 2014
|
DOI | 10.1186/s12967-014-0301-3 |
Pubmed ID | |
Authors |
Sabahattin Comertpay, Sandra Pastorino, Mika Tanji, Rosanna Mezzapelle, Oriana Strianese, Andrea Napolitano, Francine Baumann, Tracey Weigel, Joseph Friedberg, Paul Sugarbaker, Thomas Krausz, Ena Wang, Amy Powers, Giovanni Gaudino, Shreya Kanodia, Harvey I Pass, Barbara L Parsons, Haining Yang, Michele Carbone |
Abstract |
The hypothesis that most cancers are of monoclonal origin is often accepted as a fact in the scientific community. This dogma arose decades ago, primarily from the study of hematopoietic malignancies and sarcomas, which originate as monoclonal tumors. The possible clonal origin of malignant mesothelioma (MM) has not been investigated. Asbestos inhalation induces a chronic inflammatory response at sites of fiber deposition that may lead to malignant transformation after 30-50 years latency. As many mesothelial cells are simultaneously exposed to asbestos fibers and to asbestos-induced inflammation, it may be possible that more than one cell undergoes malignant transformation during the process that gives rise to MM, and result in a polyclonal malignancy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Croatia | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 50% |
Scientists | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 64 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 20% |
Student > Ph. D. Student | 11 | 17% |
Student > Bachelor | 10 | 16% |
Student > Master | 7 | 11% |
Other | 6 | 9% |
Other | 5 | 8% |
Unknown | 12 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 28% |
Medicine and Dentistry | 15 | 23% |
Agricultural and Biological Sciences | 8 | 13% |
Business, Management and Accounting | 2 | 3% |
Engineering | 2 | 3% |
Other | 5 | 8% |
Unknown | 14 | 22% |