Title |
Geroprotectors as a therapeutic strategy for COPD – where are we now?
|
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Published in |
Clinical Interventions in Aging, October 2017
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DOI | 10.2147/cia.s142483 |
Pubmed ID | |
Authors |
Joanna Miłkowska-Dymanowska, Adam J Białas, Joanna Makowska, Aleksandra Wardzynska, Paweł Górski, Wojciech J Piotrowski |
Abstract |
Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Therefore, the aim of our review was to describe and discuss some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 22% |
Student > Master | 4 | 15% |
Researcher | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Student > Postgraduate | 2 | 7% |
Other | 5 | 19% |
Unknown | 5 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Nursing and Health Professions | 6 | 22% |
Medicine and Dentistry | 5 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Engineering | 2 | 7% |
Other | 4 | 15% |
Unknown | 5 | 19% |