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Mendeley readers
Attention Score in Context
| Title |
PKA catalytic subunit mutations in adrenocortical Cushing’s adenoma impair association with the regulatory subunit
|
|---|---|
| Published in |
Nature Communications, December 2014
|
| DOI | 10.1038/ncomms6680 |
| Pubmed ID | |
| Authors |
Davide Calebiro, Annette Hannawacker, Sandra Lyga, Kerstin Bathon, Ulrike Zabel, Cristina Ronchi, Felix Beuschlein, Martin Reincke, Kristina Lorenz, Bruno Allolio, Caroline Kisker, Martin Fassnacht, Martin J. Lohse |
| Abstract |
We recently identified a high prevalence of mutations affecting the catalytic (Cα) subunit of protein kinase A (PKA) in cortisol-secreting adrenocortical adenomas. The two identified mutations (Leu206Arg and Leu199_Cys200insTrp) are associated with increased PKA catalytic activity, but the underlying mechanisms are highly controversial. Here we utilize a combination of biochemical and optical assays, including fluorescence resonance energy transfer in living cells, to analyze the consequences of the two mutations with respect to the formation of the PKA holoenzyme and its regulation by cAMP. Our results indicate that neither mutant can form a stable PKA complex, due to the location of the mutations at the interface between the catalytic and the regulatory subunits. We conclude that the two mutations cause high basal catalytic activity and lack of regulation by cAMP through interference of complex formation between the regulatory and the catalytic subunits of PKA. |
Mendeley readers
The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 46 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 26% |
| Researcher | 7 | 15% |
| Student > Master | 6 | 13% |
| Student > Postgraduate | 5 | 11% |
| Student > Bachelor | 5 | 11% |
| Other | 3 | 6% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 23% |
| Biochemistry, Genetics and Molecular Biology | 9 | 19% |
| Agricultural and Biological Sciences | 6 | 13% |
| Neuroscience | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 7 | 15% |
| Unknown | 10 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2014.
All research outputs
#4,168,073
of 22,772,779 outputs
Outputs from Nature Communications
#31,107
of 46,907 outputs
Outputs of similar age
#59,764
of 359,774 outputs
Outputs of similar age from Nature Communications
#400
of 701 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,907 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,774 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 701 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.