↓ Skip to main content

Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes

Overview of attention for article published in Breast Cancer Research, December 2014
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
2 tweeters
patent
2 patents
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

dimensions_citation
126 Dimensions

Readers on

mendeley
181 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Association of BRCA1/2defects with genomic scores predictive of DNA damage repair deficiency among breast cancer subtypes
Published in
Breast Cancer Research, December 2014
DOI 10.1186/s13058-014-0475-x
Pubmed ID
Authors

Kirsten M Timms, Victor Abkevich, Elisha Hughes, Chris Neff, Julia Reid, Brian Morris, Saritha Kalva, Jennifer Potter, Thanh V Tran, Jian Chen, Diana Iliev, Zaina Sangale, Eliso Tikishvili, Michael Perry, Andrey Zharkikh, Alexander Gutin, Jerry S Lanchbury

Abstract

IntroductionHomologous recombination (HR) DNA repair is of clinical relevance in breast cancer. Three DNA-based homologous recombination deficiency (HRD) scores (HRD-loss of heterozygosity score (LOH), HRD-telomeric allelic imbalance score (TAI), and HRD-large-scale state transition score (LST)) have been developed that are highly correlated with defects in BRCA1/2, and are associated with response to platinum therapy in triple negative breast and ovarian cancer. This study examines the frequency of BRCA1/2 defects among different breast cancer subtypes, and the ability of the HRD scores to identify breast tumors with defects in the homologous recombination DNA repair pathway.Methods215 breast tumors representing all ER/HER2 subtypes were obtained from commercial vendors. Next-generation sequencing based assays were used to generate genome wide SNP profiles, BRCA1/2 mutation screening, and BRCA1 promoter methylation data.Results BRCA1/2 deleterious mutations were observed in all breast cancer subtypes. BRCA1 promoter methylation was observed almost exclusively in triple negative breast cancer. BRCA1/2 deficient tumors were identified with BRCA1/2 mutations, or BRCA1 promoter methylation, and loss of the second allele of the affected gene. All three HRD scores were highly associated with BRCA1/2 deficiency (HRD-LOH: P =1.3¿×¿10¿17; HRD-TAI: P =1.5¿×¿10¿19; HRD-LST: P =3.5¿×¿10¿18). A combined score (HRD-mean) was calculated using the arithmetic mean of the three scores. In multivariable analyses the HRD-mean score captured significant BRCA1/2 deficiency information not captured by the three individual scores, or by clinical variables (P values for HRD-Mean adjusted for HRD-LOH: P =1.4¿×¿10¿8; HRD-TAI: P =2.9¿×¿10¿7; HRD-LST: P =2.8¿×¿10¿8; clinical variables: P =1.2¿×¿10¿16).ConclusionsThe HRD scores showed strong correlation with BRCA1/2 deficiency regardless of breast cancer subtype. The frequency of elevated scores suggests that a significant proportion of all breast tumor subtypes may carry defects in the homologous recombination DNA repair pathway. The HRD scores can be combined to produce a more robust predictor of HRD. The combination of a robust score, and the FFPE compatible assay described in this study, may facilitate use of agents targeting homologous recombination DNA repair in the clinical setting.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Singapore 1 <1%
United Kingdom 1 <1%
Argentina 1 <1%
Germany 1 <1%
Unknown 175 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 47 26%
Student > Ph. D. Student 31 17%
Student > Master 22 12%
Student > Postgraduate 13 7%
Other 11 6%
Other 33 18%
Unknown 24 13%
Readers by discipline Count As %
Medicine and Dentistry 49 27%
Biochemistry, Genetics and Molecular Biology 45 25%
Agricultural and Biological Sciences 40 22%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Computer Science 4 2%
Other 8 4%
Unknown 30 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 January 2019.
All research outputs
#2,163,690
of 14,848,875 outputs
Outputs from Breast Cancer Research
#321
of 1,596 outputs
Outputs of similar age
#43,554
of 302,041 outputs
Outputs of similar age from Breast Cancer Research
#4
of 38 outputs
Altmetric has tracked 14,848,875 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,596 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,041 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.