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Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells

Overview of attention for article published in BMC Cancer, December 2014
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  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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Title
Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells
Published in
BMC Cancer, December 2014
DOI 10.1186/1471-2407-14-922
Pubmed ID
Authors

Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Teresa Mele, Sandra R Ramírez-Clavijo, Giorgio Scagliotti, Caterina Marchiò, Anna Sapino

Abstract

In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is used as a surrogate for chromosome 17 copies, however chromosome 17 (Chr17) is frequently rearranged. The frequency and type of specific structural Chr17 alterations in breast cancer have been studied by using comparative genomic hybridization and spectral karyotyping, but not fully detailed. Actually, balanced chromosome rearrangements (e.g. translocations or inversions) and low frequency mosaicisms are assessable on metaphases using G-banding karyotype and multicolor FISH (M-FISH) only.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 23%
Student > Ph. D. Student 7 18%
Researcher 7 18%
Student > Doctoral Student 2 5%
Professor 2 5%
Other 8 20%
Unknown 5 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 35%
Agricultural and Biological Sciences 9 23%
Medicine and Dentistry 7 18%
Engineering 2 5%
Neuroscience 1 3%
Other 1 3%
Unknown 6 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2014.
All research outputs
#14,205,797
of 22,772,779 outputs
Outputs from BMC Cancer
#3,354
of 8,282 outputs
Outputs of similar age
#191,203
of 360,222 outputs
Outputs of similar age from BMC Cancer
#66
of 162 outputs
Altmetric has tracked 22,772,779 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,282 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,222 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.