| Chapter title |
MicroRNA in Immune Regulation
|
|---|---|
| Chapter number | 65 |
| Book title |
Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
|
| Published in |
Current topics in microbiology and immunology, January 2017
|
| DOI | 10.1007/82_2017_65 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-968928-9, 978-3-31-968929-6
|
| Authors |
Cheng-Jang Wu, Li-Fan Lu, Wu, Cheng-Jang, Lu, Li-Fan |
| Abstract |
The immune system protects us from enormously diverse microbial pathogens but needs to be tightly regulated to avoid deleterious immune-mediated inflammation and tissue damage. A wide range of molecular determinants and cellular components work in concert to control the magnitude and duration of a given immune response. In the past decade, microRNAs (miRNAs), a major class of small non-coding RNA species, have been extensively studied as key molecular players in immune regulation. In this chapter, we will discuss how miRNAs function as negative regulators to restrict innate and adaptive immune responses. Moreover, we will review the current reports regarding miRNAs in human immunological diseases. Finally, we will also address the emerging roles of other non-coding RNAs, long non-coding RNAs (lncRNAs) in particular, in the regulation of the immune system. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Venezuela, Bolivarian Republic of | 8 | 25% |
| United States | 2 | 6% |
| United Kingdom | 1 | 3% |
| Colombia | 1 | 3% |
| Puerto Rico | 1 | 3% |
| France | 1 | 3% |
| Spain | 1 | 3% |
| China | 1 | 3% |
| Portugal | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 15 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 31 | 97% |
| Scientists | 1 | 3% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 19% |
| Student > Doctoral Student | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Student > Ph. D. Student | 4 | 11% |
| Other | 3 | 8% |
| Other | 3 | 8% |
| Unknown | 12 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 9 | 24% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Immunology and Microbiology | 6 | 16% |
| Agricultural and Biological Sciences | 2 | 5% |
| Unknown | 14 | 38% |