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MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans

Overview of attention for article published in Infection, Genetics & Evolution, January 2018
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Title
MHC class II DRB diversity predicts antigen recognition and is associated with disease severity in California sea lions naturally infected with Leptospira interrogans
Published in
Infection, Genetics & Evolution, January 2018
DOI 10.1016/j.meegid.2017.11.023
Pubmed ID
Authors

Karina Acevedo-Whitehouse, Frances M.D. Gulland, Lizabeth Bowen

Abstract

We examined the associations between California sea lion MHC class II DRB (Zaca-DRB) configuration and diversity, and leptospirosis. As Zaca-DRB gene sequences are involved with antigen presentation of bacteria and other extracellular pathogens, we predicted that they would play a role in determining responses to these pathogenic spirochaetes. Specifically, we investigated whether Zaca-DRB diversity (number of genes) and configuration (presence of specific genes) explained differences in disease severity, and whether higher levels of Zaca-DRB diversity predicted the number of specific Leptospira interrogans serovars that a sea lion's serum would react against. We found that serum from diseased sea lions with more Zaca-DRB loci reacted against a wider array of serovars. Specific Zaca-DRB loci were linked to reactions with particular serovars. Interestingly, sea lions with clinical manifestation of leptospirosis that had higher numbers of Zaca-DRB loci were less likely to recover from disease than those with lower diversity, and those that harboured Zaca-DRB.C or -G were 4.5 to 5.3 times more likely to die from leptospirosis, regardless of the infective serovars. We propose that for leptospirosis, a disadvantage of having a wider range of antigen presentation might be increased disease severity due to immunopathology. Ours is the first study to examine the importance of Zaca-DRB diversity for antigen detection and disease severity following natural exposure to infective leptospires.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 3 15%
Student > Bachelor 3 15%
Researcher 3 15%
Student > Postgraduate 2 10%
Student > Master 2 10%
Other 7 35%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 45%
Unspecified 4 20%
Immunology and Microbiology 2 10%
Biochemistry, Genetics and Molecular Biology 1 5%
Environmental Science 1 5%
Other 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 November 2017.
All research outputs
#10,833,138
of 12,219,921 outputs
Outputs from Infection, Genetics & Evolution
#1,399
of 1,833 outputs
Outputs of similar age
#282,201
of 339,498 outputs
Outputs of similar age from Infection, Genetics & Evolution
#46
of 55 outputs
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