Title |
Experimental design and quantitative analysis of microbial community multiomics
|
---|---|
Published in |
Genome Biology, November 2017
|
DOI | 10.1186/s13059-017-1359-z |
Pubmed ID | |
Authors |
Himel Mallick, Siyuan Ma, Eric A. Franzosa, Tommi Vatanen, Xochitl C. Morgan, Curtis Huttenhower |
Abstract |
Studies of the microbiome have become increasingly sophisticated, and multiple sequence-based, molecular methods as well as culture-based methods exist for population-scale microbiome profiles. To link the resulting host and microbial data types to human health, several experimental design considerations, data analysis challenges, and statistical epidemiological approaches must be addressed. Here, we survey current best practices for experimental design in microbiome molecular epidemiology, including technologies for generating, analyzing, and integrating microbiome multiomics data. We highlight studies that have identified molecular bioactives that influence human health, and we suggest steps for scaling translational microbiome research to high-throughput target discovery across large populations. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 28 | 29% |
Canada | 5 | 5% |
Netherlands | 4 | 4% |
India | 4 | 4% |
Germany | 4 | 4% |
France | 4 | 4% |
United Kingdom | 3 | 3% |
Australia | 3 | 3% |
Spain | 3 | 3% |
Other | 10 | 10% |
Unknown | 29 | 30% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 50 | 52% |
Members of the public | 44 | 45% |
Practitioners (doctors, other healthcare professionals) | 2 | 2% |
Science communicators (journalists, bloggers, editors) | 1 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 490 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 115 | 23% |
Researcher | 107 | 22% |
Student > Master | 63 | 13% |
Student > Bachelor | 38 | 8% |
Student > Doctoral Student | 19 | 4% |
Other | 55 | 11% |
Unknown | 93 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 124 | 25% |
Biochemistry, Genetics and Molecular Biology | 88 | 18% |
Immunology and Microbiology | 51 | 10% |
Medicine and Dentistry | 29 | 6% |
Computer Science | 19 | 4% |
Other | 64 | 13% |
Unknown | 115 | 23% |