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Mendeley readers
Attention Score in Context
| Title |
Variation in time and magnitude of immune response and viremia in experimental challenges with Porcine circovirus 2b
|
|---|---|
| Published in |
BMC Veterinary Research, December 2014
|
| DOI | 10.1186/s12917-014-0286-4 |
| Pubmed ID | |
| Authors |
Taylor B Engle, Erin E Jobman, Timothy W Moural, Autumn M McKnite, Justin W Bundy, Sarah Y Barnes, Emily H Davis, Judith A Galeota, Thomas E Burkey, Graham S Plastow, Stephen D Kachman, Daniel C Ciobanu |
| Abstract |
BackgroundPorcine circovirus 2 is the primary agent responsible for inducing a group of associated diseases known as Porcine Circovirus Associated Diseases (PCVAD), which can have detrimental effects on production efficiency as well as causing significant mortality. The objective of this study was to evaluate variation in viral replication, immune response and growth across pigs (n¿=¿974) from different crossbred lines. The approach used in this study was experimental infection with a PCV2b strain of pigs at an average of 43 days of age.ResultsThe sequence of the PCV2b isolate used in the challenge was similar with a cluster of PCV2b isolates known to induce PCVAD and increased mortality rates. The swine leukocyte antigen class II (SLAII) profile of the population was diverse, with nine DQB1 haplotypes being present. Individual viremia and antibody profiles during challenge demonstrate variation in magnitude and time of viral surge and immune response. The correlations between PCV2 specific antibodies and average daily gain (ADG) were relatively low and varied between - 0.14 to 0.08 for IgM and ¿0.02 and 0.11 for IgG. In contrast, PCV2 viremia was an important driver of ADG decline following infection; a moderate negative correlation was observed between viral load and overall ADG (r¿=¿¿ 0.36, P¿<¿0.001). The pigs with the lowest 10% level of viral load maintained a steady increase in weekly ADG (P¿<¿0.0001) compared to the pigs that had the 10% greatest viral load (P¿<¿0.55). In addition, the highly viremic group expressed higher IgM and IgG starting with d 14 and d 21 respectively, and higher tumor necrosis factor ¿ alpha (TNF-¿) at d 21 (P¿<¿0.005), compared to low viremic group.ConclusionsMolecular sources of the observed differences in viremia and immune response could provide a better understanding of the host factors that influence the development of PCVAD and lead to improved knowledge of swine immunity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Denmark | 1 | 4% |
| Italy | 1 | 4% |
| Unknown | 20 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 22% |
| Researcher | 4 | 17% |
| Professor | 3 | 13% |
| Student > Master | 3 | 13% |
| Student > Doctoral Student | 2 | 9% |
| Other | 4 | 17% |
| Unknown | 2 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 12 | 52% |
| Veterinary Science and Veterinary Medicine | 5 | 22% |
| Immunology and Microbiology | 1 | 4% |
| Earth and Planetary Sciences | 1 | 4% |
| Medicine and Dentistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 3 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 December 2014.
All research outputs
#18,386,678
of 22,774,233 outputs
Outputs from BMC Veterinary Research
#1,918
of 3,045 outputs
Outputs of similar age
#261,280
of 360,775 outputs
Outputs of similar age from BMC Veterinary Research
#57
of 95 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,045 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,775 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.