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The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat

Overview of attention for article published in Journal of Pharmacy & Pharmacology, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
34 Mendeley
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Title
The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat
Published in
Journal of Pharmacy & Pharmacology, December 2014
DOI 10.1111/jphp.12341
Pubmed ID
Authors

Maria D Donovan, Fionn E O'Brien, Geraldine B Boylan, John F Cryan, Brendan T Griffin

Abstract

Recent data highlight the potential of bumetanide as a treatment for neonatal seizures and autism, as it facilitates the excitatory to inhibitory switch in gamma-aminobutyric acid signalling. This study examines the extent of blood-brain barrier (BBB) permeation of bumetanide, a key determinant of the efficacy of centrally acting drugs. Furthermore, the impact of efflux transporter organic anion transporter 3 (oat3) inhibition on bumetanide pharmacokinetics was investigated.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 21%
Student > Bachelor 7 21%
Student > Master 5 15%
Student > Doctoral Student 2 6%
Lecturer > Senior Lecturer 2 6%
Other 5 15%
Unknown 6 18%
Readers by discipline Count As %
Medicine and Dentistry 11 32%
Neuroscience 5 15%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Psychology 2 6%
Chemistry 2 6%
Other 3 9%
Unknown 9 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2014.
All research outputs
#9,692,765
of 16,932,568 outputs
Outputs from Journal of Pharmacy & Pharmacology
#2,012
of 2,597 outputs
Outputs of similar age
#135,132
of 311,681 outputs
Outputs of similar age from Journal of Pharmacy & Pharmacology
#7
of 18 outputs
Altmetric has tracked 16,932,568 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,597 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 311,681 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.