Title |
Melanoma expression of matrix metalloproteinase-23 is associated with blunted tumor immunity and poor responses to immunotherapy
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Published in |
Journal of Translational Medicine, December 2014
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DOI | 10.1186/s12967-014-0342-7 |
Pubmed ID | |
Authors |
Duane Moogk, Ines Pires da Silva, Michelle W Ma, Erica B Friedman, Eleazar Vega-Saenz de Miera, Farbod Darvishian, Patrick Scanlon, Arianne Perez-Garcia, Anna C Pavlick, Nina Bhardwaj, Paul J Christos, Iman Osman, Michelle Krogsgaard |
Abstract |
BackgroundMatrix metalloproteinase-23 (MMP-23) can block the voltage-gated potassium channel Kv1.3, whose function is important for sustained Ca2+ signaling during T cell activation. MMP-23 may also alter T cell activity and phenotype through cleavage of proteins affecting cytokine and chemokine signaling. We therefore tested the hypothesis that MMP-23 can negatively regulate the anti-tumor T cell response in human melanoma.MethodsWe characterized MMP-23 expression in primary melanoma patients who received adjuvant immunotherapy. We examined the association of MMP-23 with the anti-tumor immune response - as assessed by the prevalence of tumor-infiltrating lymphocytes and Foxp3+ regulatory T cells. Further, we examined the association between MMP-23 expression and response to immunotherapy. Considering also an in trans mechanism, we examined the association of melanoma MMP-23 and melanoma Kv1.3 expression.ResultsOur data revealed an inverse association between primary melanoma MMP-23 expression and the anti-tumor T cell response, as demonstrated by decreased tumor-infiltrating lymphocytes (TIL) (P¿=¿0.05), in particular brisk TILs (P¿=¿0.04), and a trend towards an increased proportion of immunosuppressive Foxp3+ regulatory T cells (P¿=¿0.07). High melanoma MMP-23 expression is also associated with recurrence in patients treated with immune biologics (P¿=¿0.037) but not in those treated with vaccines (P¿=¿0.64). Further, high melanoma MMP-23 expression is associated with shorter periods of progression-free survival for patients receiving immune biologics (P¿=¿0.025). On the other hand, there is no relationship between melanoma MMP-23 and melanoma Kv1.3 expression (P¿=¿0.27).ConclusionsOur data support a role for MMP-23 as a potential immunosuppressive target in melanoma, as well as a possible biomarker for informing melanoma immunotherapies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 20% |
Unknown | 4 | 80% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 32 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 19% |
Student > Bachelor | 6 | 19% |
Student > Master | 5 | 16% |
Researcher | 3 | 9% |
Student > Doctoral Student | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 31% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 7 | 22% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Medicine and Dentistry | 5 | 16% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Psychology | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 38% |