↓ Skip to main content

Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate

Overview of attention for article published in Cancer & Metabolism, December 2014
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#8 of 105)
  • High Attention Score compared to outputs of the same age (96th percentile)
  • High Attention Score compared to outputs of the same age and source (93rd percentile)

Mentioned by

news
1 news outlet
blogs
4 blogs
twitter
3 tweeters
patent
1 patent

Readers on

mendeley
151 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
Published in
Cancer & Metabolism, December 2014
DOI 10.1186/2049-3002-2-23
Pubmed ID
Authors

Jurre J Kamphorst, Michelle K Chung, Jing Fan, Joshua D Rabinowitz

Abstract

Cell growth requires fatty acids for membrane synthesis. Fatty acids are assembled from 2-carbon units in the form of acetyl-CoA (AcCoA). In nutrient and oxygen replete conditions, acetyl-CoA is predominantly derived from glucose. In hypoxia, however, flux from glucose to acetyl-CoA decreases, and the fractional contribution of glutamine to acetyl-CoA increases. The significance of other acetyl-CoA sources, however, has not been rigorously evaluated. Here we investigate quantitatively, using (13)C-tracers and mass spectrometry, the sources of acetyl-CoA in hypoxia.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Austria 1 <1%
France 1 <1%
United Kingdom 1 <1%
Portugal 1 <1%
Unknown 145 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 53 35%
Researcher 32 21%
Student > Master 11 7%
Student > Bachelor 10 7%
Student > Doctoral Student 7 5%
Other 23 15%
Unknown 15 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 32%
Biochemistry, Genetics and Molecular Biology 47 31%
Chemistry 12 8%
Medicine and Dentistry 10 7%
Immunology and Microbiology 3 2%
Other 11 7%
Unknown 19 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2016.
All research outputs
#420,509
of 12,440,542 outputs
Outputs from Cancer & Metabolism
#8
of 105 outputs
Outputs of similar age
#10,982
of 281,533 outputs
Outputs of similar age from Cancer & Metabolism
#1
of 16 outputs
Altmetric has tracked 12,440,542 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 105 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,533 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.