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Expression and evolutionary patterns of mycobacteriophage D29 and its temperate close relatives

Overview of attention for article published in BMC Microbiology, December 2017
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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5 tweeters

Citations

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Readers on

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27 Mendeley
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Title
Expression and evolutionary patterns of mycobacteriophage D29 and its temperate close relatives
Published in
BMC Microbiology, December 2017
DOI 10.1186/s12866-017-1131-2
Pubmed ID
Authors

Rebekah M. Dedrick, Travis N. Mavrich, Wei L. Ng, Graham F. Hatfull

Abstract

Mycobacteriophages are viruses that infect Mycobacterium hosts. A large collection of phages known to infect the same bacterial host strain - Mycobacterium smegmatis mc2155 - exhibit substantial diversity and characteristically mosaic architectures. The well-studied lytic mycobacteriophage D29 appears to be a deletion derivative of a putative temperate parent, although its parent has yet to be identified. Here we describe three newly-isolated temperate phages - Kerberos, Pomar16 and StarStuff - that are related to D29, and are predicted to be very close relatives of its putative temperate parent, revealing the repressor and additional genes that are lost in D29. Transcriptional profiles show the patterns of both lysogenic and lytic gene expression and identify highly-expressed, abundant, stable, small non-coding transcripts made from the Pleft early lytic promoter, and which are toxic to M. smegmatis. Comparative genomics of phages D29, Kerberos, Pomar16 and StarStuff provide insights into bacteriophage evolution, and comparative transcriptomics identifies the pattern of lysogenic and lytic expression with unusual features including highly expressed, small, non-coding RNAs.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 37%
Researcher 6 22%
Student > Bachelor 4 15%
Unspecified 1 4%
Other 1 4%
Other 2 7%
Unknown 3 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 26%
Agricultural and Biological Sciences 6 22%
Immunology and Microbiology 4 15%
Unspecified 1 4%
Social Sciences 1 4%
Other 1 4%
Unknown 7 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2018.
All research outputs
#7,691,237
of 13,352,827 outputs
Outputs from BMC Microbiology
#883
of 1,992 outputs
Outputs of similar age
#186,402
of 387,729 outputs
Outputs of similar age from BMC Microbiology
#75
of 193 outputs
Altmetric has tracked 13,352,827 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,992 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 387,729 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 193 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.