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Genome-Wide SNP-Genotyping Array to Study the Evolution of the Human Pathogen Vibrio vulnificus Biotype 3

Overview of attention for article published in PLoS ONE, December 2014
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Title
Genome-Wide SNP-Genotyping Array to Study the Evolution of the Human Pathogen Vibrio vulnificus Biotype 3
Published in
PLoS ONE, December 2014
DOI 10.1371/journal.pone.0114576
Pubmed ID
Authors

Nili Raz, Yael Danin-Poleg, Ryan B. Hayman, Yudi Bar-On, Alex Linetsky, Michael Shmoish, Eva Sanjuán, Carmen Amaro, David R. Walt, Yechezkel Kashi

Abstract

Vibrio vulnificus is an aquatic bacterium and an important human pathogen. Strains of V. vulnificus are classified into three different biotypes. The newly emerged biotype 3 has been found to be clonal and restricted to Israel. In the family Vibrionaceae, horizontal gene transfer is the main mechanism responsible for the emergence of new pathogen groups. To better understand the evolution of the bacterium, and in particular to trace the evolution of biotype 3, we performed genome-wide SNP genotyping of 254 clinical and environmental V. vulnificus isolates with worldwide distribution recovered over a 30-year period, representing all phylogeny groups. A custom single-nucleotide polymorphism (SNP) array implemented on the Illumina GoldenGate platform was developed based on 570 SNPs randomly distributed throughout the genome. In general, the genotyping results divided the V. vulnificus species into three main phylogenetic lineages and an additional subgroup, clade B, consisting of environmental and clinical isolates from Israel. Data analysis suggested that 69% of biotype 3 SNPs are similar to SNPs from clade B, indicating that biotype 3 and clade B have a common ancestor. The rest of the biotype 3 SNPs were scattered along the biotype 3 genome, probably representing multiple chromosomal segments that may have been horizontally inserted into the clade B recipient core genome from other phylogroups or bacterial species sharing the same ecological niche. Results emphasize the continuous evolution of V. vulnificus and support the emergence of new pathogenic groups within this species as a recurrent phenomenon. Our findings contribute to a broader understanding of the evolution of this human pathogen.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 25%
Student > Ph. D. Student 4 20%
Student > Bachelor 3 15%
Student > Master 2 10%
Unspecified 2 10%
Other 4 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 40%
Medicine and Dentistry 3 15%
Biochemistry, Genetics and Molecular Biology 3 15%
Unspecified 2 10%
Immunology and Microbiology 1 5%
Other 3 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2014.
All research outputs
#3,799,707
of 4,691,823 outputs
Outputs from PLoS ONE
#68,750
of 82,601 outputs
Outputs of similar age
#121,542
of 155,130 outputs
Outputs of similar age from PLoS ONE
#1,748
of 2,109 outputs
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