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Mendeley readers
| Chapter title |
Receptor-Binding and Uptake of Binary Actin-ADP-Ribosylating Toxins
|
|---|---|
| Chapter number | 46 |
| Book title |
Uptake and Trafficking of Protein Toxins
|
| Published in |
Current topics in microbiology and immunology, January 2016
|
| DOI | 10.1007/82_2016_46 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-958891-9, 978-3-31-958893-3
|
| Authors |
Panagiotis Papatheodorou, Klaus Aktories |
| Abstract |
Binary actin-ADP-ribosylating toxins (e.g., Clostridium botulinum C2 toxin or Clostridium perfringens iota toxin ) consist of two separate proteins: An ADP-ribosyltransferase, which modifies actin thereby inhibiting actin polymerization, and a binding component that forms heptamers after proteolytic activation. While C2 toxin interacts with carbohydrate structures on host cells, the group of iota-like toxins binds to lipolysis-stimulated lipoprotein receptor (LSR). Here, we review LSR and discuss the role and function of LSR in interaction of iota-like toxins with host cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 5 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 40% |
| Lecturer > Senior Lecturer | 1 | 20% |
| Student > Master | 1 | 20% |
| Unknown | 1 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 60% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 20% |
| Unknown | 1 | 20% |