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Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

Overview of attention for article published in Oncogene, December 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

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6 X users
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1 Facebook page
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3 Wikipedia pages

Citations

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82 Dimensions

Readers on

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64 Mendeley
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Title
Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis
Published in
Oncogene, December 2014
DOI 10.1038/onc.2014.411
Pubmed ID
Authors

L Zeng, A Morinibu, M Kobayashi, Y Zhu, X Wang, Y Goto, C J Yeom, T Zhao, K Hirota, K Shinomiya, S Itasaka, M Yoshimura, G Guo, E M Hammond, M Hiraoka, H Harada

Abstract

Cancer cells gain a growth advantage through the so-called Warburg effect by shifting glucose metabolism from oxidative phosphorylation to aerobic glycolysis. Hypoxia-inducible factor 1 (HIF-1) has been suggested to function in metabolic reprogramming; however, the underlying mechanism has not been fully elucidated. We found that the aberrant expression of wild-type isocitrate dehydrogenase 3α (IDH3α), a subunit of the IDH3 heterotetramer, decreased α-ketoglutarate levels and increased the stability and transactivation activity of HIF-1α in cancer cells. The silencing of IDH3α significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis. IDH3α expression was associated with the poor postoperative overall survival of lung and breast cancer patients. These results justify the exploitation of IDH3 as a novel target for the diagnosis and treatment of cancers.Oncogene advance online publication, 22 December 2014; doi:10.1038/onc.2014.411.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Japan 1 2%
Unknown 61 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 20%
Student > Ph. D. Student 10 16%
Student > Master 6 9%
Student > Bachelor 5 8%
Professor > Associate Professor 4 6%
Other 8 13%
Unknown 18 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 27%
Agricultural and Biological Sciences 14 22%
Medicine and Dentistry 6 9%
Chemistry 4 6%
Nursing and Health Professions 2 3%
Other 3 5%
Unknown 18 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2017.
All research outputs
#4,596,611
of 22,775,504 outputs
Outputs from Oncogene
#2,225
of 10,642 outputs
Outputs of similar age
#66,120
of 353,034 outputs
Outputs of similar age from Oncogene
#13
of 74 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 10,642 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,034 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.