Title |
Aberrant IDH3α expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis
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Published in |
Oncogene, December 2014
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DOI | 10.1038/onc.2014.411 |
Pubmed ID | |
Authors |
L Zeng, A Morinibu, M Kobayashi, Y Zhu, X Wang, Y Goto, C J Yeom, T Zhao, K Hirota, K Shinomiya, S Itasaka, M Yoshimura, G Guo, E M Hammond, M Hiraoka, H Harada |
Abstract |
Cancer cells gain a growth advantage through the so-called Warburg effect by shifting glucose metabolism from oxidative phosphorylation to aerobic glycolysis. Hypoxia-inducible factor 1 (HIF-1) has been suggested to function in metabolic reprogramming; however, the underlying mechanism has not been fully elucidated. We found that the aberrant expression of wild-type isocitrate dehydrogenase 3α (IDH3α), a subunit of the IDH3 heterotetramer, decreased α-ketoglutarate levels and increased the stability and transactivation activity of HIF-1α in cancer cells. The silencing of IDH3α significantly delayed tumor growth by suppressing the HIF-1-mediated Warburg effect and angiogenesis. IDH3α expression was associated with the poor postoperative overall survival of lung and breast cancer patients. These results justify the exploitation of IDH3 as a novel target for the diagnosis and treatment of cancers.Oncogene advance online publication, 22 December 2014; doi:10.1038/onc.2014.411. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 2 | 33% |
Tunisia | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Japan | 1 | 2% |
Unknown | 61 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 20% |
Student > Ph. D. Student | 10 | 16% |
Student > Master | 6 | 9% |
Student > Bachelor | 5 | 8% |
Professor > Associate Professor | 4 | 6% |
Other | 8 | 13% |
Unknown | 18 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 27% |
Agricultural and Biological Sciences | 14 | 22% |
Medicine and Dentistry | 6 | 9% |
Chemistry | 4 | 6% |
Nursing and Health Professions | 2 | 3% |
Other | 3 | 5% |
Unknown | 18 | 28% |