Title |
Creatine for women in pregnancy for neuroprotection of the fetus
|
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Published in |
Cochrane database of systematic reviews, December 2014
|
DOI | 10.1002/14651858.cd010846.pub2 |
Pubmed ID | |
Authors |
Hayley Dickinson, Emily Bain, Dominic Wilkinson, Philippa Middleton, Caroline A Crowther, David W Walker |
Abstract |
Creatine is an amino acid derivative and, when phosphorylated (phosphocreatine), is involved in replenishing adenosine triphosphate (ATP) via the creatine kinase reaction. Cells obtain creatine from a diet rich in fish, meat, or dairy and by endogenous synthesis from the amino acids arginine, glycine, and methionine in an approximate 50:50 ratio. Animal studies have shown that creatine may provide fetal neuroprotection when given to the mother through her diet in pregnancy. It is important to assess whether maternally administered creatine in human pregnancy (at times of known, suspected, or potential fetal compromise) may offer neuroprotection to the fetus and may accordingly reduce the risk of adverse neurodevelopmental outcomes, such as cerebral palsy and associated impairments and disabilities arising from fetal brain injury. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 14% |
Argentina | 1 | 14% |
United Kingdom | 1 | 14% |
Guatemala | 1 | 14% |
Unknown | 3 | 43% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 43% |
Scientists | 3 | 43% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | <1% |
Unknown | 184 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 26 | 14% |
Student > Bachelor | 20 | 11% |
Student > Ph. D. Student | 18 | 10% |
Researcher | 16 | 9% |
Student > Postgraduate | 12 | 6% |
Other | 30 | 16% |
Unknown | 63 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 50 | 27% |
Nursing and Health Professions | 19 | 10% |
Psychology | 12 | 6% |
Social Sciences | 8 | 4% |
Biochemistry, Genetics and Molecular Biology | 7 | 4% |
Other | 22 | 12% |
Unknown | 67 | 36% |