Title |
“Just a spoonful of sugar...”: import of sialic acid across bacterial cell membranes
|
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Published in |
Biophysical Reviews, December 2017
|
DOI | 10.1007/s12551-017-0343-x |
Pubmed ID | |
Authors |
Rachel A. North, Christopher R. Horne, James S. Davies, Daniela M. Remus, Andrew C. Muscroft-Taylor, Parveen Goyal, Weixiao Yuan Wahlgren, S. Ramaswamy, Rosmarie Friemann, Renwick C. J. Dobson |
Abstract |
Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon amino sugars, the most common member of which is N-acetylneuraminic acid. Once made available through the action of neuraminidases, bacterial pathogens and commensals utilise host-derived sialic acid by degrading it for energy or repurposing the sialic acid onto their own cell surface to camouflage the bacterium from the immune system. A functional sialic acid transporter has been shown to be essential for the uptake of sialic acid in a range of human bacterial pathogens and important for host colonisation and persistence. Here, we review the state-of-play in the field with respect to the molecular mechanisms by which these bio-nanomachines transport sialic acids across bacterial cell membranes. |
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Geographical breakdown
Country | Count | As % |
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Sweden | 1 | 33% |
United Kingdom | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 52 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 21% |
Researcher | 10 | 19% |
Student > Bachelor | 5 | 10% |
Other | 3 | 6% |
Student > Master | 3 | 6% |
Other | 8 | 15% |
Unknown | 12 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 17 | 33% |
Agricultural and Biological Sciences | 9 | 17% |
Chemistry | 5 | 10% |
Medicine and Dentistry | 3 | 6% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Other | 3 | 6% |
Unknown | 13 | 25% |