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Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue

Overview of attention for article published in Applied Physiology, Nutrition, and Metabolism, December 2017
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Title
Fructose-rich diet differently affects angiotensin II receptor content in the nucleus and a plasma membrane fraction of visceral adipose tissue
Published in
Applied Physiology, Nutrition, and Metabolism, December 2017
DOI 10.1139/apnm-2016-0725
Pubmed ID
Authors

Maja Bundalo, Ana Djordjevic, Biljana Bursac, Maja Zivkovic, Goran Koricanac, Aleksandra Stanković

Abstract

The adipose tissue renin-angiotensin system (RAS) is proposed to be a pathophysiological link between adipose tissue dysregulation and metabolic disorders induced by fructose rich diet (FRD). RAS can act intracellularly. We hypothesized that adipocytes nuclear membranes possess angiotensin receptors type 1 and type 2 (AT1R and AT2R) that couple to nuclear signaling pathways and regulate oxidative gene expression under the FRD. We analyzed the effect of nine-week consumption of 10% fructose solution on biochemical parameters, adipocyte morphology and expression of AT1R, AT2R, AT1R-associated protein (ATRAP), NOX4, MMP-9, and MnSOD in adipose tissue of Wistar rats. We detected AT1R and AT2R in nuclear fraction. FRD decreased protein level of nuclear angiotensin receptors, while increased AT1R and decreased AT2R levels were observed at plasma membrane. FRD increased mRNA level of ATRAP, while MnSOD mRNA and protein levels were decreased. No significant differences were observed for MMP9 and NOX4 mRNA levels. These findings coincide with hyperleptinemia, elevated blood pressure and triglyceride level, as well as with unchanged visceral adipose tissue mass and morphology upon FRD. Besides providing evidence for nuclear localization of angiotensin receptors in visceral adipose tissue, this study also points to the different effect of FRD on AT1R expression in different cellular compartments. Elevated blood pressure and decreased antioxidative capacity in visceral fat of fructose fed rats were accompanied by an increased AT1R level in plasma membrane while upregulation of ATRAP and decrease of nuclear membrane AT1R suggest an increase in capacity for attenuation of excessive AT1R signaling and visceral adiposity.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 33%
Student > Ph. D. Student 2 22%
Professor 1 11%
Student > Master 1 11%
Librarian 1 11%
Other 0 0%
Unknown 1 11%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 44%
Pharmacology, Toxicology and Pharmaceutical Science 1 11%
Computer Science 1 11%
Social Sciences 1 11%
Unknown 2 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2017.
All research outputs
#9,862,084
of 12,350,579 outputs
Outputs from Applied Physiology, Nutrition, and Metabolism
#1,129
of 1,435 outputs
Outputs of similar age
#249,589
of 349,633 outputs
Outputs of similar age from Applied Physiology, Nutrition, and Metabolism
#41
of 49 outputs
Altmetric has tracked 12,350,579 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,435 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,633 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.