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Assessment of HER-2 status in invasive breast cancer in Brazil

Overview of attention for article published in Revista da Associação Médica Brasileira, July 2017
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Assessment of HER-2 status in invasive breast cancer in Brazil
Published in
Revista da Associação Médica Brasileira, July 2017
DOI 10.1590/1806-9282.63.07.566
Pubmed ID

Victor Eduardo Arrua Arias, Helenice Gobbi, Sérgio Ossamu Ioshii, Cristovam Scapulatempo, Alexandre Rolim da Paz, Vinicius Duval da Silva, Diego Uchôa, Claudio Zettler, Fernando Augusto Soares


To characterize the frequency of HER-2-positive breast cancer in Brazil. In this prospective observational study, we first ascertained the HER-2 status of invasive breast cancer specimens by automated immunohistochemistry (IHC). For specimens classified as 2+ by IHC, we performed in situ hybridization (ISH). From February, 2011 to December, 2012, 1,495 breast specimens were registered, and 1,310 samples collected at 24 centers were analyzed. Median patient age was 54 years, and the majority of samples were obtained from segmental (46.9%) or radical mastectomy (34.4%). The predominant histological type was invasive breast carcinoma of no special type (85%), 64.3% had tubule formation (grade 3), and estrogen/progesterone receptors (ER/PR) were positive in 77.4/67.8% of the specimens analyzed, respectively. Using IHC, we found a negative HER-2 status (0 or 1+) in 72.2% of specimens, and 3+ in 18.5%; the 9.3% scored as 2+ were further analyzed by ISH, of which 15.7% were positive (thus, 20.0% of samples were HER-2- -positive by either method). We found no association between HER-2 scores and menopausal status or histological type. Tumors classified as 3+ came from younger patients, and had higher histological grade and less frequent expression of ER/PR. In the North region of Brazil, 34.7% of samples were 3+, with lower frequencies in the other four regions of the country. Our findings provide estimates for the frequency of HER-2 positivity in Brazil and raise the hypothesis that biological differences may underlie the different distribution of breast-cancer phenotypes among different Brazilian regions.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 23%
Student > Bachelor 5 16%
Other 3 10%
Student > Postgraduate 3 10%
Researcher 3 10%
Other 3 10%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 11 35%
Agricultural and Biological Sciences 4 13%
Nursing and Health Professions 2 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Engineering 2 6%
Other 4 13%
Unknown 6 19%