You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
MEK and the inhibitors: from bench to bedside
|
|---|---|
| Published in |
Journal of Hematology & Oncology, April 2013
|
| DOI | 10.1186/1756-8722-6-27 |
| Pubmed ID | |
| Authors |
Akintunde Akinleye, Muhammad Furqan, Nikhil Mukhi, Pavan Ravella, Delong Liu |
| Abstract |
Four distinct MAP kinase signaling pathways involving 7 MEK enzymes have been identified. MEK1 and MEK2 are the prototype members of MEK family proteins. Several MEK inhibitors are in clinical trials. Trametinib is being evaluated by FDA for the treatment of metastatic melanoma with BRAF V600 mutation. Selumetinib has been studied in combination with docetaxel in phase II randomized trial in previously treated patients with advanced lung cancer. Selumetinib group had better response rate and progression-free survival. This review also summarized new MEK inhibitors in clinical development, including pimasertib, refametinib, PD-0325901, TAK733, MEK162 (ARRY 438162), RO5126766, WX-554, RO4987655 (CH4987655), GDC-0973 (XL518), and AZD8330. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 176 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Hungary | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Romania | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 171 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 33 | 19% |
| Student > Ph. D. Student | 31 | 18% |
| Student > Master | 19 | 11% |
| Other | 17 | 10% |
| Student > Bachelor | 15 | 9% |
| Other | 26 | 15% |
| Unknown | 35 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 25% |
| Medicine and Dentistry | 40 | 23% |
| Biochemistry, Genetics and Molecular Biology | 33 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Chemistry | 7 | 4% |
| Other | 11 | 6% |
| Unknown | 34 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2022.
All research outputs
#2,659,013
of 24,727,020 outputs
Outputs from Journal of Hematology & Oncology
#224
of 1,268 outputs
Outputs of similar age
#21,762
of 203,242 outputs
Outputs of similar age from Journal of Hematology & Oncology
#2
of 9 outputs
Altmetric has tracked 24,727,020 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,268 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,242 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.